Temporal fluctuations in the brain’s modular architecture during movie-watching

• Published in: NeuroImage (Orlando, Fla.) Vol. 213; p. 116687
• Main Authors: Betzel, Richard F., Byrge, Lisa, Esfahlani, Farnaz Zamani, Kennedy, Daniel P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020; Elsevier Limited; Elsevier
• Subjects: Adult; Brain; Brain - physiology; Brain architecture; Brain Mapping; Cognition & reasoning; Cognitive ability; Female; Humans; Information processing; Magnetic Resonance Imaging; Male; Mental Processes - physiology; Motion Pictures; Nerve Net - physiology; Neural networks
• ISSN: 1053-8119; 1095-9572; 1095-9572
• DOI: 10.1016/j.neuroimage.2020.116687

Brain networks are flexible and reconfigure over time to support ongoing cognitive processes. However, tracking statistically meaningful reconfigurations across time has proven difficult. This has to do largely with issues related to sampling variability, making instantaneous estimation of network organization difficult, along with increased reliance on task-free (cognitively unconstrained) experimental paradigms, limiting the ability to interpret the origin of changes in network structure over time. Here, we address these challenges using time-varying network analysis in conjunction with a naturalistic viewing paradigm. Specifically, we developed a measure of inter-subject network similarity and used this measure as a coincidence filter to identify synchronous fluctuations in network organization across individuals. Applied to movie-watching data, we found that periods of high inter-subject similarity coincided with reductions in network modularity and increased connectivity between cognitive systems. In contrast, low inter-subject similarity was associated with increased system segregation and more rest-like architectures. We then used a data-driven approach to uncover clusters of functional connections that follow similar trajectories over time and are more strongly correlated during movie-watching than at rest. Finally, we show that synchronous fluctuations in network architecture over time can be linked to a subset of features in the movie. Our findings link dynamic fluctuations in network integration and segregation to patterns of inter-subject similarity, and suggest that moment-to-moment fluctuations in functional connectivity reflect shared cognitive processing across individuals.