Phosphorylation of PSD-95 at serine 73 in dCA1 is required for extinction of contextual fear

The updating of contextual memories is essential for survival in a changing environment. Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. However, the cellular and molecular mechanisms of contextual fear memory updating remain poorly understood. Postsynaptic de...

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Published inPLoS biology Vol. 21; no. 5; p. e3002106
Main Authors Ziółkowska, Magdalena, Borczyk, Malgorzata, Cały, Anna, Tomaszewski, Kamil F, Nowacka, Agata, Nalberczak-Skóra, Maria, Śliwińska, Małgorzata Alicja, Łukasiewicz, Kacper, Skonieczna, Edyta, Wójtowicz, Tomasz, Wlodarczyk, Jakub, Bernaś, Tytus, Salamian, Ahmad, Radwanska, Kasia
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.05.2023
Public Library of Science (PLoS)
Subjects
Animal cognition
Biology and Life Sciences
Changing environments
Disks Large Homolog 4 Protein - metabolism
Electron microscopy
Electrophysiology
Environmental changes
Fear
Fear - physiology
Glutamatergic transmission
Hippocampus - metabolism
Kinases
Medicine and Health Sciences
Memory
Microscopy
Molecular modelling
Morphology
Neuronal Plasticity
Phosphorylation
Postsynaptic density
Postsynaptic density proteins
Proteins
Research and Analysis Methods
Serine
Structure-function relationships
Synapses
Synapses - metabolism
Synaptic plasticity
United States > US
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Summary:The updating of contextual memories is essential for survival in a changing environment. Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. However, the cellular and molecular mechanisms of contextual fear memory updating remain poorly understood. Postsynaptic density protein 95 (PSD-95) regulates the structure and function of glutamatergic synapses. Here, using dCA1-targeted genetic manipulations in vivo, combined with ex vivo 3D electron microscopy and electrophysiology, we identify a novel, synaptic mechanism that is induced during attenuation of contextual fear memories and involves phosphorylation of PSD-95 at Serine 73 in dCA1. Our data provide the proof that PSD-95-dependent synaptic plasticity in dCA1 is required for updating of contextual fear memory.
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The authors have declared that no competing interests exist.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002106