An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis

The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation and divergence of gasdermin E.

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Bibliographic Details
Published inPLoS biology Vol. 21; no. 5; p. e3002103
Main Authors Wang, Chengliang, Ruan, Jianbin
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 04.05.2023
Public Library of Science (PLoS)
Subjects
Alzheimer's disease
Alzheimers disease
Animals
Apoptosis
Bacterial infections
Binding sites
Biology and Life Sciences
Cell death
Conservation
Defense Mechanisms
Divergence
Evolution
Gasdermins
Genes
Infections
Lancelets - metabolism
Medicine and Health Sciences
Neoplasm Proteins - metabolism
Pathogens
Pore formation
Pore-forming proteins
Primer
Pyroptosis
Pyroptosis - physiology
Regulation
Transcription factors
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Summary:The gasdermins are a family of pore-forming proteins involved in various cellular processes such as cell death and inflammation. A new study in PLOS Biology explores the evolutionary history of gasdermins across metazoans, highlighting the conservation and divergence of gasdermin E.
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The authors have declared that no competing interests exist.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3002103