The inclusion of a partial meal replacement with or without inulin to a calorie restricted diet contributes to reach recommended intakes of micronutrients and decrease plasma triglycerides: A randomized clinical trial in obese Mexican women

• Published in: Nutrition journal Vol. 11; no. 1; pp. 44 - 524
• Main Authors: Tovar, Alma Rosa, Caamaño, María del Carmen, Garcia-Padilla, Sandra, García, Olga Patricia, Duarte, Miguel Angel, Rosado, Jorge L
• Format: Journal Article
• Language: English
• Published: London BioMed Central 18.06.2012; BioMed Central Ltd; BMC
• Subjects: administration & dosage; Adolescent; Adult; adverse effects; Amino Acids, Essential; Amino Acids, Essential - administration & dosage; Amino Acids, Essential - deficiency; Amino Acids, Essential - therapeutic use; analysis; blood; Blood lipids; body composition; Body Mass Index; Clinical Nutrition; Clinical trials; Convenience foods; deficiency; Developing Countries; Diet; diet therapy; Diet, Reducing; Diet, Reducing - adverse effects; Diet, Reducing - methods; Dietary minerals; Dietary Supplements; Dietary Supplements - analysis; energy intake; etiology; fat intake; Female; Field study; Food; Health Promotion and Disease Prevention; Humans; Hypertriglyceridemia; Hypertriglyceridemia - etiology; Hypertriglyceridemia - prevention & control; Inulin; Inulin - administration & dosage; Inulin - therapeutic use; lipid content; Lipids; Longitudinal Studies; low calorie diet; Measurement; Medicine; Medicine & Public Health; methods; Mexico; Micronutrients; Micronutrients - administration & dosage; Micronutrients - deficiency; Micronutrients - therapeutic use; Middle Aged; minerals; nutrient content; Nutritional aspects; Obesity; Obesity - blood; Obesity - diet therapy; Obesity - physiopathology; Overweight; Overweight - blood; Overweight - diet therapy; Overweight - physiopathology; Partial meal replacement; Patient Dropouts; Physiological aspects; physiopathology; Plasma; prevention & control; Product development; public health; randomized clinical trials; Reducing diets; therapeutic use; triacylglycerols; Triglycerides; vitamins; waist circumference; Weight control; Weight Loss; women; Young Adult; Mexico; Obesity; Lipids; Inulin; Partial meal replacement
• ISSN: 1475-2891; 1475-2891
• DOI: 10.1186/1475-2891-11-44

Background Obesity is a major public health problem in many poor countries where micronutrient deficiencies are prevalent. A partial meal replacement may be an effective strategy to decrease obesity and increase micronutrient intake in such populations. The objective was to evaluate the efficacy of a partial meal replacement with and without inulin on weight reduction, blood lipids and micronutrients intake in obese Mexican women. Methods In a randomized controlled clinical trial 144 women (18–50 y) with BMI ≥ 25 kg/m 2 , were allocated into one of the following treatments during 3 months: 1) Two doses/d of a partial meal replacement (PMR), 2) Two doses/d of PMR with inulin (PMR + I) , 3) Two doses/d of 5 g of inulin (INU) and 4) Control group (CON). All groups received a low calorie diet (LCD). Weight, height, hip and waist circumference were measured every 2 weeks and body composition, lipids and glucose concentration and nutrient intake were assessed at baseline and after 3 months. Results All groups significantly reduced weight, BMI, waist and hip circumference. Differences between groups were only observed in BMI and weight adjusted changes: At 45 days PMR group lost more weight than INU and CON groups by 0.9 and 1.2Kg, respectively. At 60 days, PMR + I and PMR groups lost more weight than in INU by 0.7 and 1Kg, respectively. Subjects in PMR, PMR + I and INU significantly decreased triglycerides. Energy intake was reduced in all groups. Fiber intake increased in PMR + I and INU groups. Some minerals and vitamins intakes were higher in PMR and PMR + I compared with INU and CON groups. Conclusion Inclusion of PMR with and without inulin to a LCD had no additional effect on weight reduction than a LCD alone but reduced triglycerides and improved intake of micronutrients during caloric restriction. PMR could be a good alternative for obese populations with micronutrient deficiencies. ClinicalTrials.Gov ID NCT01505023