Myasthenia gravis

Bourque and Breiner present five things to know about myasthenia gravis. Among other things, myasthenia gravis causes localized muscle fatigability and weakness. Although fatigue is a common medical complaint, fatigue related to myasthenia gravis has several key features: localized muscle weakness i...

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Bibliographic Details
Published inCanadian Medical Association journal (CMAJ) Vol. 190; no. 38; p. E1141
Main Authors Bourque, Pierre R., MD, Breiner, Ari, MD
Format Journal Article
LanguageEnglish
Published Canada Joule Inc 24.09.2018
CMA Impact, Inc
Subjects
Amyotrophic lateral sclerosis
Analysis
Autoimmune diseases
Care and treatment
Diagnosis
Dyspnea
Electromyography
Immunoglobulins
Internal Medicine
Medical tests
Multiple sclerosis
Muscle fatigue
Muscle function
Myasthenia gravis
Patients
Practice
Prevalence studies (Epidemiology)
Canada
Ontario Canada
North America
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Summary:Bourque and Breiner present five things to know about myasthenia gravis. Among other things, myasthenia gravis causes localized muscle fatigability and weakness. Although fatigue is a common medical complaint, fatigue related to myasthenia gravis has several key features: localized muscle weakness in a characteristic distribution, which is exacerbated by repeated activity and worsens late in the day. Asymmetric ptosis and variable diplopia are the presenting symptoms in 60% of patients, and, in most patients, it will spread to other muscles causing fluctuating dysarthria, dysphagia, difficulty chewing and dyspnea. Limb involvement is less common but typically results in proximal weakness.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0820-3946
1488-2329
DOI:10.1503/cmaj.180656