Stem cell-based therapy for ameliorating intrauterine adhesion and endometrium injury

• Published in: Stem cell research & therapy Vol. 12; no. 1; pp. 556 - 14
• Main Authors: Song, Yu-Ting, Liu, Peng-Cheng, Tan, Jie, Zou, Chen-Yu, Li, Qian-Jin, Li-Ling, Jesse, Xie, Hui-Qi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.10.2021; BioMed Central; BMC
• Subjects: Adhesion; Amenorrhea; Classification; Connective tissue; Endometrium; Endometrium regeneration; Female; Health aspects; Humans; Infections; Infertility; Intrauterine adhesion; Menstruation; Miscarriage; Pregnancy; Regenerative medicine; Review; Stem cell research; Stem Cell Transplantation; Stem cells; Tissue Adhesions - pathology; Tissue Adhesions - therapy; Transplantation; Trauma; Uterine Diseases - pathology; Uterine Diseases - therapy; Uterus; Wound healing; Endometrium regeneration; Intrauterine adhesion; Regenerative medicine; Stem cells
• ISSN: 1757-6512; 1757-6512
• DOI: 10.1186/s13287-021-02620-2

Intrauterine adhesion refers to endometrial repair disorders which are usually caused by uterine injury and may lead to a series of complications such as abnormal menstrual bleeding, recurrent abortion and secondary infertility. At present, therapeutic approaches to intrauterine adhesion are limited due to the lack of effective methods to promote regeneration following severe endometrial injury. Therefore, to develop new methods to prevent endometrial injury and intrauterine adhesion has become an urgent need. For severely damaged endometrium, the loss of stem cells in the endometrium may affect its regeneration. This article aimed to discuss the characteristics of various stem cells and their applications for uterine tissue regeneration.