Effect of D-Sorbitol on the Thermal Gelation of Methylcellulose Formulations for Drug Delivery

The aim of this study was to examine the effect of D-sorbitol on the gelation characteristics of methylcellulose in aqueous solution. The addition of D-sorbitol at concentrations of between 25 and 30% (w/v) to 1.0—2.0% (w/v) methylcellulose solutions reduced the gelation temperature from approximate...

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Published inChemical & Pharmaceutical Bulletin Vol. 58; no. 2; pp. 247 - 249
Main Authors Itoh, Kunihiko, Hatakeyama, Tomoaki, Kimura, Tomoki, Shimoyama, Tetsuya, Miyazaki, Shozo, D'Emanuele, Antony, Attwood, David
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.02.2010
Pharmaceutical Society of Japan
Japan Science and Technology Agency
Subjects
acetaminophen
Acetaminophen - administration & dosage
Analgesics, Non-Narcotic - administration & dosage
D-sorbitol
Delayed-Action Preparations - chemistry
Diffusion
gelation
Gels - chemistry
methylcellulose
Methylcellulose - chemistry
Sorbitol - chemistry
Temperature
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Summary:The aim of this study was to examine the effect of D-sorbitol on the gelation characteristics of methylcellulose in aqueous solution. The addition of D-sorbitol at concentrations of between 25 and 30% (w/v) to 1.0—2.0% (w/v) methylcellulose solutions reduced the gelation temperature from approximately 53 °C to values between ambient and 37 °C and increased the strength of the gel. The in vitro release of acetaminophen (paracetamol) from 2.0% (w/v) methylcellulose gels containing 20—30% (w/v) D-sorbitol gel was diffusion-controlled.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.58.247