Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial

• Published in: Nutrition journal Vol. 19; no. 1; p. 1
• Main Authors: Davari, Mina, Hashemi, Reza, Mirmiran, Parvin, Hedayati, Mehdi, Sahranavard, Shamim, Bahreini, Shohreh, Tavakoly, Rahele, Talaei, Behrouz
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.01.2020; BioMed Central; BMC
• Subjects: Adult; adults; Aged; Arteriosclerosis; Atherogenesis; Atherosclerosis; B cells; Biomarkers - blood; Body mass index; Cinnamomum zeylanicum; Cinnamon; Clinical trials; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes therapy; Dietary Supplements; Double-Blind Method; Double-blind studies; Drug dosages; Enzyme-linked immunosorbent assay; Fasting; Glucose; Hs-CRP, IL-6; Humans; Inflammation; Inflammation - blood; Inflammation - drug therapy; Inflammation - etiology; Insulin resistance; Interleukin 6; Middle Aged; NF-kappa B - blood; NF-kB; NF-κB protein; noninsulin-dependent diabetes mellitus; pathogenesis; patients; placebos; Plasma levels; Product development; Sample size; SIRT1; SIRT1 protein; Sirtuin 1 - blood; Statistical analysis; Substance abuse treatment; Supplements; TNF-α; transcription factor NF-kappa B; Treatment Outcome; Tumor necrosis factor; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Type 2 diabetes; Iran; Type 2 diabetes; TNF-α; Cinnamon; Hs-CRP, IL-6; SIRT1; NF-kB

NF-kB, SIRT1 and systemic inflammation factors including hs-CRP, IL-6 and TNF-α accelerate atherosclerosis pathogenesis. Our purpose was to evaluate the effect of daily supplementation of three-gram cinnamon on plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α among type 2 diabetes patients. A ra...