Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial

• Published in: Nutrition journal Vol. 19; no. 1; p. 1
• Main Authors: Davari, Mina, Hashemi, Reza, Mirmiran, Parvin, Hedayati, Mehdi, Sahranavard, Shamim, Bahreini, Shohreh, Tavakoly, Rahele, Talaei, Behrouz
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.01.2020; BioMed Central; BMC
• Subjects: Adult; adults; Aged; Arteriosclerosis; Atherogenesis; Atherosclerosis; B cells; Biomarkers - blood; Body mass index; Cinnamomum zeylanicum; Cinnamon; Clinical trials; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes therapy; Dietary Supplements; Double-Blind Method; Double-blind studies; Drug dosages; Enzyme-linked immunosorbent assay; Fasting; Glucose; Hs-CRP, IL-6; Humans; Inflammation; Inflammation - blood; Inflammation - drug therapy; Inflammation - etiology; Insulin resistance; Interleukin 6; Middle Aged; NF-kappa B - blood; NF-kB; NF-κB protein; noninsulin-dependent diabetes mellitus; pathogenesis; patients; placebos; Plasma levels; Product development; Sample size; SIRT1; SIRT1 protein; Sirtuin 1 - blood; Statistical analysis; Substance abuse treatment; Supplements; TNF-α; transcription factor NF-kappa B; Treatment Outcome; Tumor necrosis factor; tumor necrosis factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Type 2 diabetes; Iran; Type 2 diabetes; TNF-α; Cinnamon; Hs-CRP, IL-6; SIRT1; NF-kB
• ISSN: 1475-2891; 1475-2891
• DOI: 10.1186/s12937-019-0518-3

NF-kB, SIRT1 and systemic inflammation factors including hs-CRP, IL-6 and TNF-α accelerate atherosclerosis pathogenesis. Our purpose was to evaluate the effect of daily supplementation of three-gram cinnamon on plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α among type 2 diabetes patients. A randomized, double blind, and controlled clinical trial was performed with 44 adult patients who were 25 to 70 years old with type 2 diabetes, randomized to two intervention (n = 22) and control (n = 22) groups differing by daily three grams cinnamon supplementation and placebo for 8 weeks, respectively. The plasma levels of NF-kB, SIRT, hs-CRP, IL-6 and TNF-α were measured by ELISA assay at the beginning and end of the study. After 8-week intervention, 39 subjects (n = 20 in the cinnamon and n = 19 in the placebo groups) ended up the trial. It was not observed significant difference in levels of hs-CRP (P = 0.29), TNF-α (P = 0.27), IL-6 (P = 0.52), and Sirtuin-1 (P = 0.51) in between group comparison. While, the result showed significant difference in levels of NF-kB (P = 0.02) between groups. As well as, in among group comparison, there was not observed significant differences except in hs-CRP (P = 0.008) in placebo group. This study elucidated that cinnamon supplementation has no beneficial effects in reduction of NF-kB, SIRT1, hs-CRP, IL-6 and TNF-α levels in type 2 diabetes patients which have a considerable role in development of atherogenesis.