Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases
Endosplasmic reticulum aminopeptidase 1 ( ERAP1 ), endoplasmic reticulum aminopeptidase 2 ( ERAP2 ) and puromycin-sensitive aminopeptidase ( NPEPPS ) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family. NPEPPS catalyzes the processing of proteosome-der...
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Published in | Genes and immunity Vol. 15; no. 8; pp. 521 - 527 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.12.2014
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Endosplasmic reticulum aminopeptidase 1 (
ERAP1
), endoplasmic reticulum aminopeptidase 2 (
ERAP2
) and puromycin-sensitive aminopeptidase (
NPEPPS
) are key zinc metallopeptidases that belong to the oxytocinase subfamily of M1 aminopeptidase family.
NPEPPS
catalyzes the processing of proteosome-derived peptide repertoire followed by trimming of antigenic peptides by
ERAP1
and
ERAP2
for presentation on major histocompatibility complex (MHC) Class I molecules. A series of genome-wide association studies have demonstrated associations of these aminopeptidases with a range of immune-mediated diseases such as ankylosing spondylitis, psoriasis, Behçet’s disease, inflammatory bowel disease and type I diabetes, and significantly, genetic interaction between some aminopeptidases and HLA Class I loci with which these diseases are strongly associated. In this review, we highlight the current state of understanding of the genetic associations of this class of genes, their functional role in disease, and potential as therapeutic targets. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1466-4879 1476-5470 |
DOI: | 10.1038/gene.2014.46 |