Impact of weight gain on the evolution and regression of prediabetes: a quantitative analysis

• Published in: European journal of clinical nutrition Vol. 71; no. 2; pp. 206 - 211
• Main Authors: Nakasone, Y, Miyakoshi, T, Sato, Y, Yamauchi, K, Hashikura, R, Takayama, M, Hirabayashi, K, Koike, H, Aizawa, T
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2017; Nature Publishing Group
• Subjects: 631/443; 692/699; Adult; Blood Glucose - analysis; Blood Glucose - metabolism; Body Mass Index; Clinical Nutrition; Development and progression; Diabetes; Diabetes mellitus; Disease Progression; Epidemiology; Evolution; Female; Follow-Up Studies; Glucose; Glucose Tolerance Test; Health aspects; Humans; Internal Medicine; Logistic Models; Longitudinal Studies; Male; Medicine; Medicine & Public Health; Men; Metabolic Diseases; Metabolic disorders; Middle Aged; Obesity; Odds Ratio; original-article; Prediabetic state; Prediabetic State - blood; Prediabetic State - physiopathology; Public Health; Quantitative analysis; Regression analysis; Retrospective Studies; Risk Factors; Sex Factors; Weight Gain; Weight loss; Women; Womens health; Japan
• ISSN: 0954-3007; 1476-5640
• DOI: 10.1038/ejcn.2016.118

Background/Objectives: The quantitative impact of weight gain on prediabetic glucose dysregulation remains unknown; only one study quantitated the impact of weight loss. We quantified the impact of weight gain on the evolution and regression of prediabetes (PDM). Subjects/Methods: In 4234 subjects without diabetes, using logistic regression analysis with a 4.8-year follow-up period, we analyzed the relationship between (1) δBMI (BMI follow-up−basal ) and the progression from normal glucose regulation (NGR) to PDM or diabetes, and (2) δBMI and the regression from PDM to NGR. Results: Mean (±s.d.) δBMI was 0.17 (±1.3) kg/m 2 in subjects with NGR and δBMI was positively and independently related to progression (adjusted odds ratio (OR adj ) (95% CI), 1.24 (1.15–1.34), P <0.01). Mean (±s.d.) δBMI was −0.03 (±1.25) kg/m 2 in those with PDM and δBMI was negatively related to the regression (OR adj , 0.72 (0.65–0.80), P <0.01). The relation of δBMI to the progression was significant in men (OR adj , 1.42 (1.28–1.59), P <0.01) but not in women (OR adj , 1.05 (0.94–1.19), P =0.36). Also, the negative impact of δBMI on the regression was significant only in men (men, OR adj , 0.65 (0.57–0.75), P <0.01; women, OR adj , 0.94 (0.77–1.14), P =0.51). Conclusions: In Japanese adults, an increase in the BMI by even 1 kg/m 2 was related to 24% increase in the risk of development of PDM or diabetes in NGR subjects and was related to 28% reduction in the regression from PDM to NGR. In women, we did not note any significant impact of weight gain on the evolution or regression of PDM.