Mapping Functional Connectivity Using Cerebral Blood Flow in the Mouse Brain

Brain function can be assessed from resting-state functional connectivity (rs-fc) maps, most commonly created by analyzing the dynamics of cerebral hemoglobin concentration. Here, we develop the use of Laser Speckle Contrast Imaging (LSCI) for mapping rs-fc using cerebral blood flow (CBF) dynamics....

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Published inJournal of cerebral blood flow and metabolism Vol. 35; no. 3; pp. 367 - 370
Main Authors Bergonzi, Karla M, Bauer, Adam Q, Wright, Patrick W, Culver, Joseph P
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.03.2015
Sage Publications Ltd
Nature Publishing Group
Subjects
Animals
Brain - blood supply
Brain - physiology
Brain Mapping - methods
Brief Communication
Cerebrovascular Circulation - physiology
Male
Mice
Neural Pathways - physiology
brain imaging
neurovascular coupling
cortical mapping
intrinsic optical imaging
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Summary:Brain function can be assessed from resting-state functional connectivity (rs-fc) maps, most commonly created by analyzing the dynamics of cerebral hemoglobin concentration. Here, we develop the use of Laser Speckle Contrast Imaging (LSCI) for mapping rs-fc using cerebral blood flow (CBF) dynamics. Because LSCI is intrinsically noisy, we used spatial and temporal averaging to sufficiently raise the signal-to-noise ratio for observing robust functional networks. Although CBF-based rs-fc maps in healthy mice are qualitatively similar to simultaneously-acquired [HbO2]-based maps, some quantitative regional differences were observed. These combined flow/concentration maps might help clarify mechanisms involved in network disruption during disease.
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ISSN:0271-678X
1559-7016
DOI:10.1038/jcbfm.2014.211