POP levels in breast milk and maternal serum and thyroid hormone levels in mother–child pairs from Uppsala, Sweden

• Published in: Environment international Vol. 36; no. 2; pp. 180 - 187
• Main Authors: Darnerud, P.O., Lignell, S., Glynn, A., Aune, M., Törnkvist, A., Stridsberg, Mats
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.02.2010; Elsevier
• Subjects: Adolescent; Adult; Biological and medical sciences; Blood; Breast; Chemical and industrial products toxicology. Toxic occupational diseases; Children; DDE; Dichlorodiphenyl Dichloroethylene - blood; Dichlorodiphenyl Dichloroethylene - metabolism; Dioxins; DOE; Environmental Monitoring; Environmental Pollutants - blood; Environmental Pollutants - metabolism; Female; Homeostasis - drug effects; Hormones; Humans; Infant; Infant, Newborn; Male; Maternal Exposure; Maternal-Fetal Exchange; Medical sciences; MEDICIN; Medicin och hälsovetenskap; MEDICINE; Milk; Milk, Human - metabolism; Organic Chemicals - blood; Organic Chemicals - metabolism; PCB; Polychlorinated biphenyls; Polychlorinated Biphenyls - blood; Polychlorinated Biphenyls - metabolism; Polychlorinated Dibenzodioxins - analogs & derivatives; Polychlorinated Dibenzodioxins - blood; Polychlorinated Dibenzodioxins - metabolism; Pregnancy; Sampling; Serums; Sweden; Thyroid hormone; Thyroid Hormones - metabolism; Toxicology; TSH; Various organic compounds; Young Adult; Sweden; Europe; Sweden, Uppsala; T4; DDE; Dioxins; TSH; Thyroid hormone; PCB; T3; Human; Biological fluid; Dioxin derivatives; Polychlorobiphenyls; Thyroid stimulating hormone; Epidemiology; Persistent organic pollutant; Halogenated hydrocarbon; Mother; Chlorine Organic compounds; Chlorocarbon; Child; Public health; Organic compounds; Breast milk
• ISSN: 0160-4120; 1873-6750; 1873-6750
• DOI: 10.1016/j.envint.2009.11.001

In experimental studies, it has frequently been observed that the homeostasis of thyroid hormones (THs) is affected by exposure to persistent organic pollutants (POPs), such as dioxins and PCBs. In man, similar effects have been indicated in several epidemiological studies. In order to investigate the possible effect on THs at low background exposures found among the Swedish population the following study was performed. Primiparous women ( n = 395) in the Uppsala region were recruited between 1996 and 1999. Of these, 325 mothers agreed to donate a serum sample in late pregnancy and breast milk was obtained from 211 women 3 weeks after delivery. Babies were sampled for blood at 3 weeks ( n = 150) and 3 months ( n = 115) after birth. In connection to the sampling, questions on personal characteristics were asked. Levels of low (tri- to penta-) chlorinated PCB, di- ortho PCB, p, p′-DDE, (mono- ortho) PCB TEQ and PCDD/DF TEQ were monitored in breast milk and in mother's blood (not PCDD/DF). The results showed that the measured TH levels (thyroid-stimulating hormone — TSH, total tri-iodothyronine — TT3, free thyroxine — FT4) in mothers and children were within the reference range. Some significant associations were seen between POP exposures and TH levels in mother or child after simple regression analysis. Following adjustment for important confounding factors, the significant associations mostly disappeared. However, significantly decreasing TT3 levels with increasing prenatal low-chlorinated PCB exposure were still seen in 3 week old children, and on TT3 in mothers exposed to PCDD/DF. In conclusion, the study clearly shows the importance of adjustment for important confounding factors in the analysis of possible associations between POP exposure and hormonal effects. The remaining associations are weak in both children and mothers and the clinical consequences of these alterations are uncertain. When comparing studies that investigate associations between TH levels and POP levels during the perinatal stage, no obvious between-study concordance was seen regarding the critical dose for hormonal effects to occur.