Assessment of the pre-emptive effect of photobiomodulation in the postoperative period of impacted lower third molar extractions: A randomized, controlled, double-blind study protocol

• Published in: PloS one Vol. 19; no. 6; p. e0300136
• Main Authors: Salaberry, Daniel Rodríguez, Bruno, Laura Hermida, Cirisola, Rolf Wilhem Consolandich, Longo, Priscila Larcher, Chavantes, Maria Cristina, Navarro, Ricardo Scarparo, Gonçalves, Marcela Letícia Leal, Sobral, Ana Paula Taboada, Gimenez, Thais, Duran, Cinthya Cosme Gutierrez, Motta, Lara Jansiski, Bussadori, Sandra Kalil, Horliana, Anna Carolina Ratto Tempestini, Mesquita Ferrari, Raquel Agnelli, Fernandes, Kristianne Porta Santos
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.06.2024; Public Library of Science (PLoS)
• Subjects: Adult; Analgesics; Analysis; Anti-inflammatory agents; Biology and Life Sciences; Calibration; Care and treatment; Corticosteroids; Double-Blind Method; Drugs; Dysphagia; Edema; Edema - etiology; Edema - prevention & control; Engineering and Technology; Female; Humans; Lasers; Light-emitting diodes; Low-Level Light Therapy - methods; Male; Medicine and Health Sciences; Molar, Third - surgery; Pain; Pain, Postoperative - prevention & control; Paracetamol; Patient compliance; Patients; Postoperative Complications - etiology; Postoperative Complications - prevention & control; Postoperative Period; Randomized Controlled Trials as Topic; Research ethics; Study Protocol; Surgery; Surgical outcomes; Tooth Extraction - adverse effects; Tooth Extraction - methods; Tooth extractions; Tooth, Impacted - surgery; Uruguay
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0300136

Photobiomodulation is a safe option for controlling pain, edema, and trismus when applied postoperatively in third molar surgery. However, administration prior to surgery has been under-explored. This study aims to explore the effectiveness of pre-emptive photobiomodulation in reducing postoperative edema in impacted lower third molar extractions. Two groups of healthy individuals undergoing tooth extraction will be randomly assigned: Control group receiving pre-emptive corticosteroid and simulated photobiomodulation, and Photobiomodulation Group receiving intraoral low-intensity laser and extraoral LED cluster application. The primary outcome will be postoperative edema after 48 h. The secondary outcomes will be pain, trismus dysphagia, and analgesic intake (paracetamol). These outcomes will be assessed at baseline as well as two and seven days after surgery. Adverse effects will be recorded. Data will be presented as means ± SD and a p-value < 0.05 will be indicative of statistical significance.