Comparative Analysis of Matrix Metalloproteinase Family Members Reveals That MMP9 Predicts Survival and Response to Temozolomide in Patients with Primary Glioblastoma

• Published in: PloS one Vol. 11; no. 3; p. e0151815
• Main Authors: Li, Qingbin, Chen, Baoshi, Cai, Jinquan, Sun, Ying, Wang, Guangzhi, Li, Yongli, Li, Ruiyan, Feng, Yan, Han, Bo, Li, Jianlong, Tian, Yu, Yi, Liye, Jiang, Chuanlu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.03.2016; Public Library of Science (PLoS)
• Subjects: Adults; Biology; Biology and life sciences; Biomarkers; Biomarkers, Tumor - metabolism; Brain; Brain cancer; Brain research; Brain tumors; Cancer therapies; Chemotherapy; Comparative analysis; Complications and side effects; Correlation; Dacarbazine - analogs & derivatives; Dacarbazine - pharmacology; Dacarbazine - therapeutic use; Datasets; Development and progression; Disease Progression; DNA Methylation - drug effects; Dosage and administration; Drug therapy; Extracellular matrix; Gelatinase B; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Genetic aspects; Genomes; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - enzymology; Glioblastoma - genetics; Glioblastomas; Glioma; Hazards; Hospitals; Humans; Kaplan-Meier Estimate; Matrix metalloproteinase; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Matrix metalloproteinases; Medical prognosis; Medical research; Medicine and Health Sciences; Metalloproteinase; Metastases; Methylation; Modulators; Neoplasm Grading; Neurosurgery; Patient outcomes; Patients; Physical Sciences; Prognosis; Proportional Hazards Models; Radiation therapy; Regression analysis; Regression models; Research and Analysis Methods; RNA, Messenger - genetics; RNA, Messenger - metabolism; Studies; Survival; Survival Analysis; Temozolomide; Treatment Outcome; Tumors; Zinc; China

Glioblastoma multiform (GBM) is the most common malignant primary brain tumor in adults. Radiotherapy plus concomitant and adjuvant TMZ chemotherapy is the current standard of care for patients with GBM. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are key modulators...