Impairment of Colour Vision in Diabetes with No Retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SNDREAMS- II, Report 3)

• Published in: PloS one Vol. 10; no. 6; p. e0129391
• Main Authors: Gella, Laxmi, Raman, Rajiv, Kulothungan, Vaitheeswaran, Pal, Swakshyar Saumya, Ganesan, Suganeswari, Sharma, Tarun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.06.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Anemia; Blood pressure; Cataracts; Color; Color vision; Color Vision - genetics; Diabetes; Diabetes mellitus; Diabetic neuropathy; Diabetic retinopathy; Diabetic Retinopathy - epidemiology; Diabetic Retinopathy - genetics; Diabetic Retinopathy - physiopathology; Diabetics; Epidemiology; Error analysis; Etiology; Evaluation; Eye surgery; Female; Genetics; Glaucoma; Heart rate; Humans; Hypertension; Impairment; India - epidemiology; Intraocular pressure; Logistic Models; Male; Middle Aged; Molecular Biology; Molecular chains; Molecular genetics; Photography; Population studies; Retina; Retinopathy; Risk analysis; Risk Factors; Statistical analysis; Stereophotography; Vision; India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0129391

To assess impairment of colour vision in type 2 diabetics with no diabetic retinopathy and elucidate associated risk factors in a population-based cross-sectional study. This is part of Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular-genetics Study (SN-DREAMS II) which was conducted between 2007-2010. FM 100 hue-test was performed in 253 subjects with no clinical evidence of diabetic retinopathy. All subjects underwent detailed ophthalmic evaluation including cataract grading using LOCS III and 45° 4-field stereoscopic fundus photography. Various ocular and systemic risk factors for impairment of colour vision (ICV) were assessed in subjects with diabetes but no retinopathy. P value of < 0.05 was considered statistically significant. The mean age of the study sample was 57.08 ± 9.21 (range: 44-86 years). Gender adjusted prevalence of ICV among subjects with diabetes with no retinopathy was 39.5% (CI: 33.5-45.5). The mean total error score in the study sample was 197.77 ± 100 (range: 19-583). The risk factors for ICV in the study were women OR: 1.79 (1.00-3.18), increased resting heart rate OR: 1.04 (1.01-1.07) and increased intraocular pressure OR: 1.12 (1.00-1.24). Significant protective factor was serum high-density lipoprotein OR: 0.96 (0.93-0.99). Acquired ICV is an early indicator of neurodegenerative changes in the retina. ICV found in diabetic subjects without retinopathy may be of non-vascular etiology.