Quality Control of Motor Unit Number Index (MUNIX) Measurements in 6 Muscles in a Single-Subject “Round-Robin” Setup

• Published in: PloS one Vol. 11; no. 5; p. e0153948
• Main Authors: Neuwirth, Christoph, Burkhardt, Christian, Alix, James, Castro, José, de Carvalho, Mamede, Gawel, Malgorzata, Goedee, Stephan, Grosskreutz, Julian, Lenglet, Timothée, Moglia, Cristina, Omer, Taha, Schrooten, Maarten, Weber, Markus
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.05.2016; Public Library of Science (PLoS)
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - diagnosis; Biology and Life Sciences; Biomarkers; Coefficient of variation; Control methods; Disease; Electrodes; Electromyography - methods; Electromyography - standards; Female; Healthy Volunteers; Hospitals; Humans; Laboratories; Male; Measurement methods; Medicine and Health Sciences; Motor neurons; Motor Neurons - physiology; Motor task performance; Muscle Strength - physiology; Muscle, Skeletal - innervation; Muscles; Neurology; Neuromuscular diseases; Neuromuscular Diseases - diagnosis; Neurons; Neurophysiology; Neurosciences; Quality control; Reliability analysis; Reproducibility of Results; Research and Analysis Methods; Sensitivity and Specificity; Studies; Variability; Portugal; Switzerland

Motor Unit Number Index (MUNIX) is a neurophysiological measure that provides an index of the number of lower motor neurons in a muscle. Its performance across centres in healthy subjects and patients with Amyotrophic Lateral Sclerosis (ALS) has been established, but inter-rater variability between...