Mammary candidiasis: A medical condition without scientific evidence?

• Published in: PloS one Vol. 12; no. 7; p. e0181071
• Main Authors: Jiménez, Esther, Arroyo, Rebeca, Cárdenas, Nivia, Marín, María, Serrano, Pilar, Fernández, Leonides, Rodríguez, Juan M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.07.2017; Public Library of Science (PLoS)
• Subjects: Analysis; Antibiotics; Bacterial infections; Bacterial Typing Techniques - methods; Bacteriocins - isolation & purification; Biology and Life Sciences; Biopsy; Breast; Breast - microbiology; Breast Feeding; Breastfeeding & lactation; Candidiasis; Candidiasis - diagnosis; Coagulase; Consultants; Female; Food science; Gram-positive bacteria; Health aspects; Humans; Identification methods; Infectious diseases; Laboratories; Lactation; Libraries; Mastitis; Medical personnel; Medicine and Health Sciences; Microbiological analysis; Microorganisms; Microscopy; Midwifery; Milk; Milk, Human - microbiology; Nipples; Nomenclature; Nutrition; Pain; Pathogens; Physicians; Pumps; Research and Analysis Methods; Risk factors; Streptococcus - isolation & purification; Studies; Womens health; Yeasts; Spain
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0181071

Many physicians, midwives and lactation consultants still believe that yeasts (particularly Candida spp.) play an important role as an agent of nipple and breast pain despite the absolute absence of scientific proofs to establish such association. In this context, the objective of this study was to investigate the microorganisms involved in sore nipples and/or painful "shooting" breastfeeding by using a variety of microscopy techniques, as well as culture-dependent and-independent identification methods. Initially, 60 women (30 diagnosed as suffering "mammary candidiasis" and 30 with no painful breastfeeding) were recruited to elucidate the role of their pumps on the milk microbial profiles. After realizing the bias introduced by using such devices, manual expression was selected as the collection method for the microbiological analysis of milk samples provided by 529 women with symptoms compatible with "mammary candidiasis". Nipple swabs and nipple biopsy samples were also collected from the participating women. Results showed that the role played by yeasts in breast and nipple pain is, if any, marginal. In contrast, our results strongly support that coagulase-negative staphylococci and streptococci (mainly from the mitis and salivarius groups) are the agents responsible for such cases. As a consequence, and following the recommendations of the US Library of Medicine for the nomenclature of infectious diseases, the term "mammary candidiasis" or "nipple thrush" should be avoided when referring to such condition and replaced by "subacute mastitis".