High Serum Carotenoids Associated with Lower Risk for Bone Loss and Osteoporosis in Post-Menopausal Japanese Female Subjects: Prospective Cohort Study

• Published in: PloS one Vol. 7; no. 12; p. e52643
• Main Authors: Sugiura, Minoru, Nakamura, Mieko, Ogawa, Kazunori, Ikoma, Yoshinori, Yano, Masamichi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.12.2012; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Alcohol use; Antioxidants; Asian Continental Ancestry Group; Beta carotene; Biocompatibility; Bone Density; Bone loss; Bone mineral density; Carotenoids; Carotenoids - blood; Cohort analysis; Confidence intervals; Development and progression; Epidemiology; Female; Follow-Up Studies; Fruits; Health risk assessment; Humans; Japan - epidemiology; Male; Medicine; Menopause; Middle Aged; Osteopenia; Osteoporosis; Osteoporosis - blood; Osteoporosis - epidemiology; Perimenopause; Polls & surveys; Postmenopausal women; Prospective Studies; Radius; Risk; Studies; Surveys; β-Carotene; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0052643

Recent epidemiological studies show that high intakes of carotenoids might be useful to maintain bone health, but little is known about the association of serum carotenoids with change of bone mineral density (BMD). The objective of this study was to investigate longitudinally whether serum carotenoids are associated with bone loss. We conducted a follow-up on 146 male and 99 pre- and 212 post-menopausal female subjects from the Mikkabi study. Those who participated in previous BMD surveys and completed four years of follow-up were examined longitudinally. During a 4-year follow-up, 15 of the post-menopausal female subjects developed new-onset osteoporosis. In contrast, none of the male and pre-menopausal female subjects did. In male and pre-menopausal female subjects, the six serum carotenoids at the baseline were not associated with bone loss. On the other hand, in post-menopausal female subjects, the 4-year bone loss of radius was inversely associated with the serum carotenoid concentrations, especially in β-carotene. After adjustments for confounders, the odds ratios (OR) for osteoporosis in the highest tertiles of serum β-carotene and β-cryptoxanthin against the lowest tertiles were 0.24 (95% confidence interval 0.05-1.21) and 0.07 (CI: 0.01-0.88), respectively. Serum β-cryptoxanthin was also inversely associated with the risk for osteopenia and/or osteoporosis (P for trend, 0.037). In addition, our retrospective analysis revealed that subjects who developed osteoporosis and/or osteopenia during the survey period had significantly lower serum concentrations of β-cryptoxanthin and β-carotene at the baseline than those in the normal group. Antioxidant carotenoids, especially β-cryptoxanthin and β-carotene, are inversely associated with the change of radial BMD in post-menopausal female subjects.