Association of the incidence of atopic dermatitis until 3 years old with climate conditions in the first 6 months of life: Japan Environment and Children's Study (JECS)

• Published in: PloS one Vol. 17; no. 5; p. e0268204
• Main Authors: Yokomichi, Hiroshi, Mochizuki, Mie, Shinohara, Ryoji, Kushima, Megumi, Horiuchi, Sayaka, Kojima, Reiji, Ooka, Tadao, Akiyama, Yuka, Miyake, Kunio, Otawa, Sanae, Yamagata, Zentaro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.05.2022; Public Library of Science (PLoS)
• Subjects: Age; Atopic dermatitis; Biology and Life Sciences; Birth; Children; Children & youth; Climate; Climatic conditions; Dermatitis; Earth Sciences; Eczema; Food allergies; Health risks; Mean temperatures; Medicine and Health Sciences; Meteorological data; Minimum temperatures; People and Places; Physical Sciences; Pressure; Questionnaires; Seasons; Standard deviation; Vapor pressure; Vapors; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0268204

To determine the climate conditions that affect the incidence of atopic dermatitis from infancy to 3 years old. We analyzed 100,303 children born from 2011 to 2014 for follow-up until 3 years old using cohort data from the Japan Environment and Children's Study. The study included 15 Regional Centers, including 19 prefectures across Japan. We used meteorological data of the Japan Meteorological Agency. We calculated the hazard ratio (HR) of the standard deviation and low vs. high mean values of several climate conditions in children in their first 6 months of life to determine the incidence of atopic dermatitis. The Kaplan-Meier curve showed that children born in the months of October to December had the highest incidence of atopic dermatitis. Among climate conditions, a one standard deviation increase in the temperature (HR = 0.87), minimum temperature (HR = 0.87), and vapor pressure (HR = 0.87) showed the lowest HRs for the incidence of atopic dermatitis. These results were confirmed by an analysis by strata of the birth season. A low vapor pressure (HR = 1.26, p<0.0001) and the combination of a low mean temperature or low mean minimum temperature and low vapor pressure (HR = 1.26, p<0.0001) were associated with the highest incidence of atopic dermatitis. These results were consistent when they were adjusted for a maternal and paternal history of allergy and the prefecture of birth. Among climate conditions, a low vapor pressure is the most strongly associated with a high incidence of atopic dermatitis. Measuring vapor pressure may be useful for preventing atopic dermatitis.