Nutritional Supplementation Is a Necessary Complement to Dietary Counseling among Tuberculosis and Tuberculosis-HIV Patients

• Published in: PloS one Vol. 10; no. 8; p. e0134785
• Main Authors: Bacelo, Adriana Costa, Ramalho, Andrea, Brasil, Pedro Emmanuel, Cople-Rodrigues, Cláudia Dos Santos, Georg, Ingebourg, Paiva, Eliane, Argolo, Sheila Vasques Leandro, Rolla, Valeria Cavalcanti, Rolla, Valeria Cavalcante
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.08.2015; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; Adult; Adults; AIDS; Analysis; Anemia; Biomarkers; Body Composition; Body composition (biology); Body mass; Body Mass Index; Brazil; Care and treatment; Clinical trials; Complications and side effects; Counseling; Counseling - standards; Diabetes; Diet; Dietary Supplements; Female; Follow-Up Studies; Food; HIV; HIV Infections - complications; HIV patients; Human immunodeficiency virus; Humans; Infections; Infectious diseases; Iron; Laboratories; Male; Malnutrition; Malnutrition - diet therapy; Malnutrition - etiology; Medical diagnosis; Micronutrients; Mycobacterium tuberculosis; Nutrition; Nutrition Therapy - standards; Nutritional Status; Oxidative stress; Patients; Physiological aspects; Proteins; Selenium; Therapy; Trajectory analysis; Tuberculosis; Tuberculosis - complications; Brazil; Rio de Janeiro Brazil
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0134785

The Brazilian Ministry of Health and the World Health Organization recommend dietary counseling for patients with malnutrition during tuberculosis treatment. Patients under tuberculosis therapy (infected and not infected with HIV) were followed-up to evaluate the effectiveness of dietary counseling. describe the nutritional status of patients with tuberculosis. an observational follow-up study over a 180-day period of tuberculosis therapy in adults was conducted. Subjects were assessed for body composition (using BMI, TSF and MUAC parameters), serum biomarkers and offered dietary counseling. The data obtained at each visit (D15, D30, D60, D90, D120, D150, and D180) were analyzed, showing trajectories over time and central tendencies each time. at baseline, the mean age was 41.1 (± 13.4) years; they were predominantly male, with income lower than a local minimum wage and at least six years of schooling. Patients showed predominantly pulmonary tuberculosis. At baseline, all patients suffered from malnutrition. The overall energy malnutrition prevalence was of 70.6%. Anemia at baseline was observed in both groups (63.2%), however, it was significantly more pronounced in the HIV+. At the end, energy malnutrition was reduced to 57.1% (42.9% of HIV- and 71.4% of the HIV+). Micronutrients malnutrition was evident in 71.4% of the HIV- patients and 85.7% of HIV+ patients at the end of tuberculosis therapy. Using BMI (≤ 18.5 kg/m2cutoff) as an index of malnutrition, it was detected in 23.9% of the HIV- and 27.3% of the HIV+ patients at baseline, with no evident improvement over time; using TSF (≤ 11.4mm as cutoff) or MUAC (≤ 28.5cm as cutoff), malnutrition was detected in 70.1% and 85.3% of all patients, respectively. Nevertheless, combining all biomarkers, at the end of follow-up, all patients suffered from malnutrition. Although with a limited number of patients, the evidence does not support that dietary counseling is effective to recover from malnutrition in our population.