Identification of serum microRNA signatures for diagnosis of mild traumatic brain injury in a closed head injury model

• Published in: PloS one Vol. 9; no. 11; p. e112019
• Main Authors: Sharma, Anuj, Chandran, Raghavendar, Barry, Erin S, Bhomia, Manish, Hutchison, Mary Anne, Balakathiresan, Nagaraja S, Grunberg, Neil E, Maheshwari, Radha K
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.11.2014; Public Library of Science (PLoS)
• Subjects: Acoustic startle response; Animals; Behavior, Animal; Bioinformatics; Biology and Life Sciences; Brain; Brain - physiopathology; Brain injuries; Brain Injuries - blood; Brain Injuries - complications; Brain Injuries - diagnosis; Brain Injuries - genetics; Computational Biology; Diagnosis; Diagnostic systems; Gene Expression Profiling; Head injuries; Head Injuries, Closed - complications; Health risks; Injuries; Injury analysis; Laboratories; Locomotion; Male; Medical diagnosis; Mice; Mice, Inbred C57BL; MicroRNA; MicroRNAs - blood; MicroRNAs - genetics; miRNA; Neurological diseases; Reflex, Startle; Ribonucleic acid; RNA; Rodents; Startle response; Stem cells; Traumatic brain injury; United States > US; Maryland; Iraq

Wars in Iraq and Afghanistan have highlighted the problems of diagnosis and treatment of mild traumatic brain injury (mTBI). MTBI is a heterogeneous injury that may lead to the development of neurological and behavioral disorders. In the absence of specific diagnostic markers, mTBI is often unnotice...