Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility

• Published in: PloS one Vol. 9; no. 8; p. e105236
• Main Authors: Kuo, Ho-Chang, Huang, Ying-Hsien, Chien, Shu-Chen, Yu, Hong-Ren, Hsieh, Kai-Sheng, Hsu, Yu-Wen, Chang, Wei-Chiao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.08.2014; Public Library of Science (PLoS)
• Subjects: Alleles; Analysis; Aneurysms; Biology and Life Sciences; Case-Control Studies; Cell adhesion; Cell Adhesion Molecules - genetics; Children; Consent; Coronary artery; Coronary Artery Disease - genetics; Coronary Artery Disease - pathology; Coronary vessels; DC-SIGN protein; Dendritic cells; Dengue fever; Deoxyribonucleic acid; Disease susceptibility; DNA; Etiology; Gene Frequency; Genetic aspects; Genetic Association Studies; Genetic diversity; Genetic Predisposition to Disease; Genetic variance; Genetic Variation; Genomes; Genotype; Haplotypes; Hospitals; Humans; Immunoglobulins; Immunoglobulins, Intravenous - therapeutic use; Infections; Inflammation; Integrins; Intravenous administration; Kawasaki disease; Lectins; Lectins, C-Type - genetics; Lesions; Linkage Disequilibrium; Medicine; Medicine and Health Sciences; Mucocutaneous lymph node syndrome; Mucocutaneous Lymph Node Syndrome - diagnosis; Mucocutaneous Lymph Node Syndrome - genetics; Mucocutaneous Lymph Node Syndrome - therapy; Pediatrics; Pharmacy; Polymorphism, Single Nucleotide; Receptors, Cell Surface - genetics; Risk analysis; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Systemic vasculitis; Tagging; Treatment Outcome; Tuberculosis; Vasculitis; Veins & arteries; Beijing China; Japan; China; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0105236

Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility. This study was conducted to investigate the association between genetic polymorphisms of CD209 and the risk KD. A total of 948 subjects (381 KD and 567 controls) were recruited. Nine tagging SNPs (rs8112310, rs4804800, rs11465421, rs1544766, rs4804801, rs2287886, rs735239, rs735240, rs4804804) were selected for TaqMan allelic discrimination assay. Clinical phenotypes, coronary artery lesions (CAL) and intravenous immunoglobulin (IVIG) treatment outcomes were collected for analysis. Significant associations were found between CD209 polymorphisms (rs4804800, rs2287886, rs735240) and the risk of KD. Haplotype analysis for CD209 polymorphisms showed that A/A/G haplotype (P = 0.0002, OR = 1.61) and G/A/G haplotype (P = 0.0365, OR = 1.52) had higher risk of KD as compared with G/G/A haplotype in rs2287886/rs735239/rs735240 pairwise allele analysis. There were no significant association in KD with regards to CAL formation and IVIG treatment responses. CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness.