Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters
A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal st...
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| Published in | PloS one Vol. 10; no. 3; p. e0119440 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
05.03.2015
Public Library of Science (PLoS) |
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| Abstract | A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity. |
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| AbstractList | A series of N -ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity. A series of N -ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity. A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity.A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity. |
| Audience | Academic |
| Author | Chandraju, Siddegowda Fun, Hoong-Kun Win, Yip-Foo Chidan Kumar, C. S. Loh, Wan-Sin Quah, Ching Kheng Tan, Weng Kang |
| AuthorAffiliation | 3 Department of Sugar Technology & Chemistry, University of Mysore, Sir M.V. PG Center, Tubinakere, Karnataka, India 5 Klinik Kesihatan Batu Kawa, Jalan Stapok Utara/ Utara, Kuching, Sarawak, Malaysia 6 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia 2 Department of Chemistry, Alva’s Institute of Engineering & Technology, Mijar, Karnataka, India 4 Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, Perak, Malaysia The University of Iowa, UNITED STATES 1 X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia |
| AuthorAffiliation_xml | – name: 2 Department of Chemistry, Alva’s Institute of Engineering & Technology, Mijar, Karnataka, India – name: 3 Department of Sugar Technology & Chemistry, University of Mysore, Sir M.V. PG Center, Tubinakere, Karnataka, India – name: 6 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia – name: The University of Iowa, UNITED STATES – name: 1 X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia – name: 4 Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, Perak, Malaysia – name: 5 Klinik Kesihatan Batu Kawa, Jalan Stapok Utara/ Utara, Kuching, Sarawak, Malaysia |
| Author_xml | – sequence: 1 givenname: C. S. surname: Chidan Kumar fullname: Chidan Kumar, C. S. – sequence: 2 givenname: Wan-Sin surname: Loh fullname: Loh, Wan-Sin – sequence: 3 givenname: Siddegowda surname: Chandraju fullname: Chandraju, Siddegowda – sequence: 4 givenname: Yip-Foo surname: Win fullname: Win, Yip-Foo – sequence: 5 givenname: Weng Kang surname: Tan fullname: Tan, Weng Kang – sequence: 6 givenname: Ching Kheng surname: Quah fullname: Quah, Ching Kheng – sequence: 7 givenname: Hoong-Kun surname: Fun fullname: Fun, Hoong-Kun |
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| CitedBy_id | crossref_primary_10_1007_s00216_020_02585_w crossref_primary_10_1007_s00894_016_3130_x crossref_primary_10_1007_s13738_024_03012_y crossref_primary_10_14233_ajchem_2019_22185 crossref_primary_10_1002_adsc_202200502 crossref_primary_10_1107_S2056989018017425 crossref_primary_10_1515_zkri_2018_2090 crossref_primary_10_2174_1570179417666200325124712 crossref_primary_10_2174_0929867330666230426154055 crossref_primary_10_2174_1573406414666180525082038 crossref_primary_10_1080_13510002_2017_1364330 crossref_primary_10_1021_acs_joc_0c01991 |
| Cites_doi | 10.1248/cpb.42.1817 10.1515/zkri-2013-1709 10.1002/anie.199515551 10.1021/jf001146k 10.5897/AJPP10.156 10.1107/S0021889808042726 10.1016/j.tetlet.2009.01.035 10.1007/s00604-007-0777-0 10.5264/eiyogakuzashi.44.307 10.1016/S0960-894X(98)00558-7 10.1021/ja306538w 10.1016/j.bmcl.2004.12.012 10.1016/S0014-827X(03)00185-X 10.2174/138161207782794284 10.1107/S0108767307043930 |
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| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Chidan Kumar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2015 Chidan Kumar et al 2015 Chidan Kumar et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: CSCK. Performed the experiments: CSCK WSL. Analyzed the data: CSCK WSL SC YFW. Contributed reagents/materials/analysis tools: CKQ HKF. Wrote the paper: CSCK WSL SC YFW WKT CKQ HKF. Competing Interests: The authors have declared that no competing interests exist. |
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| Snippet | A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of... A series of N -ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of... A series of N -ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of... |
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| SubjectTerms | Analgesics Antioxidants Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Chemical synthesis Crystal structure Crystallography Esters Esters - chemical synthesis Esters - chemistry Esters - pharmacology Free Radical Scavengers - chemistry Molecular Structure Nitrogen Observations Organic chemistry Organic light emitting diodes Oxidation-Reduction Pharmaceutical industry Pharmacological research Pharmacy Phthalimide Phthalimides - chemical synthesis Phthalimides - chemistry Phthalimides - pharmacology Physics Properties Stability analysis Structure-activity relationships (Pharmacology) Studies X ray analysis X-Ray Diffraction |
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| Title | Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/25742494 https://www.proquest.com/docview/1660924748 https://www.proquest.com/docview/1661325514 https://pubmed.ncbi.nlm.nih.gov/PMC4351070 https://doaj.org/article/97fde3765bd346a29dc7e628a750e46f http://dx.doi.org/10.1371/journal.pone.0119440 |
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