Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters

• Published in: PloS one Vol. 10; no. 3; p. e0119440
• Main Authors: Chidan Kumar, C. S., Loh, Wan-Sin, Chandraju, Siddegowda, Win, Yip-Foo, Tan, Weng Kang, Quah, Ching Kheng, Fun, Hoong-Kun
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.03.2015; Public Library of Science (PLoS)
• Subjects: Analgesics; Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Chemical synthesis; Crystal structure; Crystallography; Esters; Esters - chemical synthesis; Esters - chemistry; Esters - pharmacology; Free Radical Scavengers - chemistry; Molecular Structure; Nitrogen; Observations; Organic chemistry; Organic light emitting diodes; Oxidation-Reduction; Pharmaceutical industry; Pharmacological research; Pharmacy; Phthalimide; Phthalimides - chemical synthesis; Phthalimides - chemistry; Phthalimides - pharmacology; Physics; Properties; Stability analysis; Structure-activity relationships (Pharmacology); Studies; X ray analysis; X-Ray Diffraction; Penang Malaysia; Malaysia; India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0119440

A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity.