Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection

• Published in: PloS one Vol. 12; no. 4; p. e0175844
• Main Authors: Seshadri, Chetan, Sedaghat, Nafiseh, Campo, Monica, Peterson, Glenna, Wells, Richard D., Olson, Gregory S., Sherman, David R., Stein, Catherine M., Mayanja-Kizza, Harriet, Shojaie, Ali, Boom, W. Henry, Hawn, Thomas R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.04.2017; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Adults; Age; Antibiotics; Antigens; Antiinfectives and antibacterials; Arthritis; Assaying; Bacillus Calmette-Guerin vaccine; BCG; Bioinformatics; Biology and Life Sciences; Blood; Body mass; Case-Control Studies; CCR5 protein; Cell activation; Cell culture; Children; Chromosome 11; Computation; Computer and Information Sciences; Computer programs; Cryopreservation; Cytokines - genetics; Diabetes mellitus; Diagnosis; Disease resistance; Drug Resistance, Bacterial - genetics; Drugs; Engineering; Enrichment; Enrollments; Epidemiology; Exposure; Female; Gene expression; Gene Regulatory Networks - genetics; Gene set enrichment analysis; Genetic aspects; Genomes; Health risks; Historical account; HIV; Hospitals; Households; Human immunodeficiency virus; Humans; Immune response; Immune system; Immunological memory; Infections; Infectious diseases; Inflammation; Inflammation - genetics; Inhibition; Inhibitors; Interferon; Latent Tuberculosis - genetics; Lymphoma; Male; Mathematical analysis; Medicine; Medicine and Health Sciences; Microbial drug resistance; Monocytes - drug effects; Mutation; Mycobacterium tuberculosis; Mycobacterium tuberculosis - pathogenicity; Nucleic acids; Oxidative phosphorylation; Pharmacology; Proteins; Rheumatoid arthritis; Risk; Risk factors; Skin; Small Molecule Libraries - therapeutic use; Statistical analysis; Statistics; Studies; Topology; Transcription; Transcription (Genetics); Transcription, Genetic - genetics; Tuberculosis; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - genetics; Young Adult; Cleveland Ohio; Uganda; Ohio; United States > US; Kampala Uganda

Understanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV. To compare the early transcriptional response of M.tb-infected monocytes between Ugandan household contacts of tuberc...