Formation of hydrogen sulfide from cysteine in Saccharomyces cerevisiae BY4742: genome wide screen reveals a central role of the vacuole

• Published in: PloS one Vol. 9; no. 12; p. e113869
• Main Authors: Winter, Gal, Cordente, Antonio G, Curtin, Chris
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.12.2014; Public Library of Science (PLoS)
• Subjects: Accumulation; Acidification; Adenosine triphosphatase; Amino acids; ATPases; Baking yeast; Biodegradation; Biology and Life Sciences; Biosynthesis; Catabolism; Clonal deletion; Cysteine; Cysteine - metabolism; Cystine; Degradation; Enzymes; Eukaryotes; Fermentation; Folic acid; Gas detectors; Gene Deletion; Genes; Genetic aspects; Genome, Fungal - genetics; Genomes; Genomics; H+-transporting ATPase; Haploidy; Homeostasis; Hydrogen; Hydrogen sulfide; Hydrogen Sulfide - metabolism; Iron; Mammals; Metabolism; Mitochondria; Mitochondria - metabolism; Mutants; Physiological aspects; Physiological effects; Proteins; Ribonucleic acid; RNA; RNA processing; Saccharomyces; Saccharomyces cerevisiae; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Sulfide; Sulfur; Thiols; Toxicity; Vacuoles - metabolism; Yeast

Discoveries on the toxic effects of cysteine accumulation and, particularly, recent findings on the many physiological roles of one of the products of cysteine catabolism, hydrogen sulfide (H2S), are highlighting the importance of this amino acid and sulfur metabolism in a range of cellular activiti...