Pre-Conception Dyslipidemia Is Associated with Development of Preeclampsia and Gestational Diabetes Mellitus

• Published in: PloS one Vol. 10; no. 10; p. e0139164
• Main Authors: Baumfeld, Yael, Novack, Lena, Wiznitzer, Arnon, Sheiner, Eyal, Henkin, Yakov, Sherf, Michael, Novack, Victor
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.10.2015; Public Library of Science (PLoS)
• Subjects: Adult; Blood; Blood pressure; Body mass index; Cholesterol; Cholesterol, HDL - blood; Complications; Complications and side effects; Demographic aspects; Diabetes; Diabetes mellitus; Diabetes, Gestational - blood; Diabetes, Gestational - etiology; Dyslipidemia; Dyslipidemias; Dyslipidemias - blood; Dyslipidemias - complications; Exercise; Fasting; Female; Fertility; Gestational diabetes; Glucose; Glucose tolerance; Gynecology; Health risk assessment; Humans; Hypertension; Intolerance; Lipids; Lipoproteins; Mathematical models; Metabolic disorders; Metabolic syndrome; Morbidity; Obstetrics; Physical fitness; Population; Pre-eclampsia; Pre-Eclampsia - blood; Pre-Eclampsia - etiology; Preeclampsia; Pregnancy; Pregnancy complications; Risk factors; Studies; Triglycerides; Triglycerides - blood; Weight control; Womens health; Young Adult; Israel
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0139164

The association between glucose intolerance, elevated blood pressure and abnormal lipid levels is well established and comprises the basis of metabolic syndrome pathophysiology. We hypothesize that abnormal preconception lipid levels are associated with the increased risk of severe pregnancy complications such as preeclampsia and gestational diabetes mellitus. We included all singleton deliveries (n = 27,721) of women without known cardiovascular morbidity and preeclampsia and gestational diabetes mellitus during previous pregnancies. Association between preconception low high density lipoprotein cholesterol (HDLc level≤50 mg/dL), high triglycerides (level≥150 mg/dL) and the primary outcome (composite of gestational diabetes mellitus/or preeclampsia) was assessed using Generalized Estimation Equations. Primary outcome of preeclampsia and/or gestational diabetes was observed in a total of 3,243 subjects (11.7%). Elevated triglycerides and low HDLc were independently associated with the primary outcome: with odds ratio (OR) of 1.61 (95% CI 1.29-2.01) and OR = 1.33 (95% CI 1.09-1.63), respectively, after adjusting for maternal age, weight, blood pressure, repeated abortions, fertility treatments and fasting glucose. There was an interaction between the effects of HDLc≤50 mg/dL and triglycerides≥150 mg/dL with an OR of 2.69 (95% CI 1.73-4.19). Our analysis showed an increased rate of preeclampsia and/or gestational diabetes in women with low HDLc and high triglycerides values prior to conception. In view of the severity of these pregnancy complications, we believe this finding warrants a routine screening for the abnormal lipid profile among women of a child-bearing age.