High Intrathoracic Anastomosis with Thoracoscopy Is Safe and Feasible for Treatment of Esophageal Squamous Cell Carcinoma

• Published in: PloS one Vol. 11; no. 3; p. e0152151
• Main Authors: Jeon, Hyun Woo, Park, Jae Kil, Song, Kyo Young, Sung, Sook Whan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.03.2016; Public Library of Science (PLoS)
• Subjects: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anastomosis; Anastomosis, Surgical - methods; Biology and Life Sciences; Biopsy; Carcinoma, Squamous Cell - surgery; Care and treatment; Complications and side effects; Dissection; Endoscopy; Esophageal cancer; Esophageal Neoplasms - surgery; Esophageal Squamous Cell Carcinoma; Esophagus; Esophagus - surgery; Female; Health aspects; Heart surgery; Hospitals; Humans; Intensive Care Units; Laparoscopy; Laparoscopy - methods; Lymph Node Excision; Lymph nodes; Lymphatic system; Male; Medicine; Medicine and Health Sciences; Metastases; Middle Aged; Minimally Invasive Surgical Procedures; Morbidity; Mortality; Neck; Neoplasm Recurrence, Local; Operative Time; Ostomy; Patient Safety; Patients; Postoperative Period; Retrospective Studies; Sepsis; Squamous cell carcinoma; Stomach; Surgery; Surgical anastomosis; Thoracic surgery; Thoracoscopy; Thoracoscopy - methods; Thorax; Tomography; Treatment Outcome
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0152151

Minimally invasive esophagectomy (MIE) has the potential to reduce the morbidity and mortality of esophageal cancer surgery. Esophageal squamous cell carcinoma (ESCC) has a high incidence of earlier lymphatic spread and is usually located more proximal to the incisor than esophageal adenocarcinoma; consequently, the anastomosis should be made more proximal in the thorax or in the neck. We adopted the proximal intrathoracic anastomotic technique using thoracoscopy for mid-to-lower ESCC. From October 2010 to August 2014, fifty-eight consecutive patients underwent MIE for ESCC. After laparoscopic gastric tubing, thoracoscopic esophageal resection and reconstruction were performed using a 28-mm circular stapler following radical mediastinal lymph node dissection. We tried to make an anastomosis at the apex of the chest. Postoperative outcomes, including overall survival and recurrence, were assessed. The mean patient age was 64.3±9 years. The mean operative time was 371.8±51.6 minutes, and the duration of the thorax procedure was 254.8±38.3 minutes. The mean number of lymph nodes dissected was 31±11.7. The mean intensive care unit (ICU) stay and hospital stay were 3.5±8.2 hours and 13.6±7.4 days, respectively. The level of anastomosis was 22.3±1.8cm from the incisor. One patient died of uncontrolled sepsis due to necrosis of the gastric graft. Two patients developed small contained leakage. Nine patients exhibited distant metastasis during the follow-up period. Thoracoscopic intrathoracic anastomosis at the proximal esophagus is feasible and safe.