Prevalence of Dyslipidemia in Urban and Rural India: The ICMR–INDIAB Study

• Published in: PloS one Vol. 9; no. 5; p. e96808
• Main Authors: Joshi, Shashank R., Anjana, Ranjit Mohan, Deepa, Mohan, Pradeepa, Rajendra, Bhansali, Anil, Dhandania, Vinay K., Joshi, Prashant P., Unnikrishnan, Ranjit, Nirmal, Elangovan, Subashini, Radhakrishnan, Madhu, Sri Venkata, Rao, Paturi Vishnupriya, Das, Ashok Kumar, Kaur, Tanvir, Shukla, Deepak Kumar, Mohan, Viswanathan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.05.2014; Public Library of Science (PLoS)
• Subjects: Abnormalities; Adult; Age Distribution; Aged; Aged, 80 and over; Anthropometry; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Councils; Diabetes; Diabetes mellitus; Disease prevention; Dyslipidemia; Dyslipidemias - blood; Dyslipidemias - epidemiology; Female; Glucose; Glucose tolerance; Health education; Health risks; High density lipoprotein; Humans; Hypercholesterolemia; Hypertriglyceridemia; India - epidemiology; Lipids; Lipids - blood; Low density lipoprotein; Low density lipoproteins; Male; Medical research; Medicine and Health Sciences; Metabolic disorders; Metabolic syndrome; Middle Aged; Obesity; Population; Prevalence; Prevalence studies (Epidemiology); Research and Analysis Methods; Response rates; Risk analysis; Risk factors; Risk management; Rural areas; Rural Population - statistics & numerical data; Rural populations; Sample size; Sampling designs; Sex Distribution; Studies; Territory; Urban Population - statistics & numerical data; Young Adult; India
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0096808

To study the pattern and prevalence of dyslipidemia in a large representative sample of four selected regions in India. Phase I of the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study was conducted in a representative population of three states of India [Tamil Nadu, Maharashtra and Jharkhand] and one Union Territory [Chandigarh], and covered a population of 213 million people using stratified multistage sampling design to recruit individuals ≥20 years of age. All the study subjects (n = 16,607) underwent anthropometric measurements and oral glucose tolerance tests were done using capillary blood (except in self-reported diabetes). In addition, in every 5th subject (n = 2042), a fasting venous sample was collected and assayed for lipids. Dyslipidemia was diagnosed using National Cholesterol Education Programme (NCEP) guidelines. Of the subjects studied, 13.9% had hypercholesterolemia, 29.5% had hypertriglyceridemia, 72.3% had low HDL-C, 11.8% had high LDL-C levels and 79% had abnormalities in one of the lipid parameters. Regional disparity exists with the highest rates of hypercholesterolemia observed in Tamilnadu (18.3%), highest rates of hypertriglyceridemia in Chandigarh (38.6%), highest rates of low HDL-C in Jharkhand (76.8%) and highest rates of high LDL-C in Tamilnadu (15.8%). Except for low HDL-C and in the state of Maharashtra, in all other states, urban residents had the highest prevalence of lipid abnormalities compared to rural residents. Low HDL-C was the most common lipid abnormality (72.3%) in all the four regions studied; in 44.9% of subjects, it was present as an isolated abnormality. Common significant risk factors for dyslipidemia included obesity, diabetes, and dysglycemia. The prevalence of dyslipidemia is very high in India, which calls for urgent lifestyle intervention strategies to prevent and manage this important cardiovascular risk factor.