Using oxidized low-density lipoprotein autoantibodies to predict restenosis after balloon angioplasty in patients with acute myocardial infarction

• Published in: PloS one Vol. 8; no. 10; p. e74726
• Main Authors: Huang, Ching-Hui, Chang, Chia-Chu, Huang, Ching-Shan, Kuo, Chen-Ling, Chen, Ching-Pei, Hsia, Chien-Hsun, Chang, Yung-Ming, Chen, Hung-Te, Feng, Chih-Chung, Lin, Lee-Shin, Yang, Po-Ta, Tsai, Chen-Dao, Lin, Chih-Sheng, Liu, Chin-San
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.10.2013; Public Library of Science (PLoS)
• Subjects: Acute Disease; Analysis; Angina pectoris; Angiography; Angioplasty; Angioplasty, Balloon, Coronary; Arteriosclerosis; Atherosclerosis; Autoantibodies; Autoantibodies - blood; Autoantibodies - immunology; Autoimmunity; Balloon angioplasty; Biomarkers; Blood lipids; Blood plasma; Cardiac patients; Cardiology; Cardiovascular disease; Cardiovascular diseases; Carotid arteries; Cholesterol; Coronary Restenosis - blood; Coronary Restenosis - complications; Coronary Restenosis - diagnosis; Density; Diabetes; Electrocardiography; Female; Health risks; Heart attack; Heart attacks; Heart diseases; Hospitals; Humans; Infarction; Internal medicine; Lesions; Linear Models; Lipoproteins; Lipoproteins, LDL - blood; Lipoproteins, LDL - immunology; Low density lipoprotein; Low density lipoproteins; Male; Medical prognosis; Medical research; Medicine; Middle Aged; Myocardial infarction; Myocardial Infarction - complications; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - therapy; Patients; Plasma; Prognosis; Radiography; Restenosis; Risk; Risk reduction; Stenosis; Thrombolysis; Trend analysis; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0074726

Oxidized low-density lipoproteins (oxLDL) and oxidized low-density lipoprotein autoantibodies (OLAB) have been detected in human plasma and atherosclerotic lesions. OLAB appear to play a role in the clearance of oxLDL from circulation. Higher levels of OLAB appear to be associated with a reduced risk of a wide range of cardiovascular diseases. We investigated the prognostic value of plasma oxLDL and OLAB in patients undergoing primary coronary balloon angioplasty for acute ST-elevation myocardial infarction (STEMI). Plasma oxLDL and OLAB concentrations were measured in 56 patients with acute STEMI before primary angioplasty, and then 3 days, 7 days and 1 month after the acute event. Follow-up angiography was repeated 6 months later to detect the presence of restensosis (defined as >50% luminal diameter stenosis). The thrombolysis in myocardial infarction (TIMI) risk score was calculated to determine the relationship between OLAB/oxLDL ratio and TIMI risk scores. Of the 56 patients, 18 (31%) had angiographic evidence of restenosis. Plasma OLAB concentrations were significantly lower in the restenosis group before angioplasty (181±114 vs. 335±257 U/L, p = 0.003), and at day 3 (155±92 vs. 277±185 U/L, p<0.001) and day 7 (177±110 vs. 352±279 U/L, p<0.001) after the acute event. There was no difference in oxLDL concentration between the two groups. The ratio of OLAB/oxLDL positively correlated with TIMI risk scores before angioplasty (p for trend analysis, p = 0.004), at day 3 (p = 0.008) and day 7 (p<0.001) after STEMI. A relative deficit of OLAB, and hence likely impaired clearance of oxLDL, is associated with the risk of arterial restenosis after primary angioplasty for acute STEMI.