Yarrow supercritical extract exerts antitumoral properties by targeting lipid metabolism in pancreatic cancer

• Published in: PloS one Vol. 14; no. 3; p. e0214294
• Main Authors: Mouhid, Lamia, Gómez de Cedrón, Marta, García-Carrascosa, Elena, Reglero, Guillermo, Fornari, Tiziana, Ramírez de Molina, Ana
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.03.2019; Public Library of Science (PLoS)
• Subjects: Achillea - chemistry; Achillea - metabolism; Adjuvant chemotherapy; Analysis; Animals; Anticancer properties; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Apoptosis; Biocompatibility; Biology and Life Sciences; Cancer; Cancer cells; Cancer therapies; Carbon dioxide; Cell growth; Cell Line, Tumor; Cell Movement - drug effects; Chemotherapy; Cholesterol; Cytotoxicity; Desaturase; Dietary supplements; Down-Regulation - drug effects; Enzymes; Fatty Acid Synthases - genetics; Fatty Acid Synthases - metabolism; Fatty acid synthesis; Fatty acids; Fatty-acid synthase; Food science; Genes; Genomics; Health aspects; Homeostasis; Humans; Lipid metabolism; Lipid Metabolism - drug effects; Lipids; Male; Malignancy; Medical prognosis; Medicine and Health Sciences; Metabolism; Mice; Mice, Nude; Molecular modelling; Oncology; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - pathology; Phytochemicals; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Protein Isoforms - antagonists & inhibitors; Protein Isoforms - genetics; Protein Isoforms - metabolism; Proteins; Research and Analysis Methods; Stearoyl-CoA desaturase; Stearoyl-CoA Desaturase - genetics; Stearoyl-CoA Desaturase - metabolism; Sterol Regulatory Element Binding Protein 1 - antagonists & inhibitors; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Sterols; Supercritical gas extraction; Toxicity; Transplantation, Heterologous; Tumors; Xenografts; Xenotransplantation; Spain
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0214294

Metabolic reprogramming is considered a hallmark of cancer. Currently, the altered lipid metabolism in cancer is a topic of interest due to the prominent role of lipids regulating the progression of various types of tumors. Lipids and lipid-derived molecules have been shown to activate growth regulatory pathways and to promote malignancy in pancreatic cancer. In a previous work, we have described the antitumoral properties of Yarrow (Achillea Millefolium) CO2 supercritical extract (Yarrow SFE) in pancreatic cancer. Herein, we aim to investigate the underlaying molecular mechanisms by which Yarrow SFE induces cytotoxicity in pancreatic cancer cells. Yarrow SFE downregulates SREBF1 and downstream molecular targets of this transcription factor, such as fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD). Importantly, we demonstrate the in vivo effect of Yarrow SFE diminishing the tumor growth in a xenograft mouse model of pancreatic cancer. Our data suggest that Yarrow SFE can be proposed as a complementary adjuvant or nutritional supplement in pancreatic cancer therapy.