CD105 expression on CD34-negative spindle-shaped stromal cells of primary tumor is an unfavorable prognostic marker in early breast cancer patients

• Published in: PloS one Vol. 10; no. 3; p. e0121421
• Main Authors: Martinez, Leandro Marcelo, Labovsky, Vivian, Calcagno, María de Luján, Davies, Kevin Mauro, Garcia Rivello, Hernán, Rivello, Hernán Garcia, Bianchi, Maria Silvia, Wernicke, Alejandra, Vallone, Valeria Beatriz Fernández, Fernández Vallone, Valeria Beatriz, Chasseing, Norma Alejandra
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.03.2015; Public Library of Science (PLoS)
• Subjects: Actins - metabolism; Adult; Aged; Aged, 80 and over; Analysis; Antigens, CD - metabolism; Antigens, CD34 - metabolism; Biology; Biomarkers, Tumor - metabolism; Bone marrow; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer; CD105 antigen; CD146 Antigen - metabolism; CD34 antigen; Collagen; Councils; Development and progression; Disease-Free Survival; Endoglin; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Hospitals; Humans; Infiltration; Laboratories; Medicine; Metastases; Metastasis; Middle Aged; Mortality; Neoplasm Metastasis; Patients; Prognosis; Receptors, Cell Surface - metabolism; Recurrence; Retrospective Studies; Stem cells; Stromal cells; Stromal Cells - metabolism; Stromal Cells - pathology; Survival; Tumor Microenvironment; Tumors; Womens health; Argentina

Several studies have confirmed that the breast tumor microenvironment drives cancer progression and metastatic development. The aim of our research was to investigate the prognostic significance of the breast tumor microenvironment in untreated early breast cancer patients. Therefore, we analyzed th...