Maternal obesity in pregnancy and children's cardiac function and structure: A systematic review and meta-analysis of evidence from human studies

• Published in: PloS one Vol. 17; no. 11; p. e0275236
• Main Authors: den Harink, Tamara, Roelofs, Manouck J M, Limpens, Jacqueline, Painter, Rebecca C, Roseboom, Tessa J, van Deutekom, Arend W
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.11.2022; Public Library of Science (PLoS)
• Subjects: Age; Animals; Bias; Biology and Life Sciences; Blood pressure; Body mass index; Cardiac function; Cardiovascular disease; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Child; Children; Cohort analysis; Complications and side effects; Congenital diseases; Cross-sectional studies; Diabetes; Female; Fetuses; Health aspects; Health risks; Heart; Heart diseases; Heart rate; Humans; Infant; Literature reviews; Magnetic resonance imaging; Medicine and Health Sciences; Meta-analysis; Obesity; Obesity - complications; Obesity, Maternal; Offspring; Pediatrics; People and Places; Physical Sciences; Pregnancy; Pregnant women; Research and Analysis Methods; Reviews; Risk factors; Structure-function relationships; Systematic review; Ventricle; Womens health; Netherlands
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0275236

The prevalence of obesity is increasing worldwide. Experimental animal studies demonstrate that maternal obesity during pregnancy directly affects cardiac structure and function in their offspring, which could contribute to their increased cardiovascular disease (CVD) risk. Currently, a systematic overview of the available evidence regarding maternal obesity and alterations in cardiac structure and function in human offspring is lacking. We systematically searched the electronic databases Embase, MEDLINE and NARCIS from inception to June 29, 2022 including human studies comparing cardiac structure and function from fetal life onwards in offspring of women with and without obesity. The review protocol was registered with PROSPERO International Prospective Register of Systematic Reviews (identifier: CRD42019125071). Risk of bias was assessed using a modified Newcastle-Ottawa scale. Results were expressed using standardized mean differences (SMD). The search yielded 1589 unique publications, of which thirteen articles were included. Compared to offspring of women without obesity, fetuses of women with obesity had lower left ventricular strain, indicative of reduced systolic function, that persisted in infancy (SMD -2.4, 95% confidence interval (CI) -4.4 standard deviation (SD) to -0.4 SD during fetal life and SMD -1.0, 95% CI -1.6 SD to -0.3 SD in infancy). Furthermore, infants born to women with obesity had a thicker interventricular septum (SMD 0.6 SD, 95% CI 0.0 to 1.2 SD) than children born to women without obesity. In conclusion, cardiac structure and function differs between fetuses and children of women with and without obesity. Some of these differences were present in fetal life, persisted in childhood and are consistent with increased CVD risk. Long-term follow-up research is warranted, as studies in offspring of older age are lacking.