Clinical and microbiological characteristics of perianal infections in adult patients with acute leukemia

• Published in: PloS one Vol. 8; no. 4; p. e60624
• Main Authors: Chen, Chien-Yuan, Cheng, Aristine, Huang, Shang-Yi, Sheng, Wang-Huei, Liu, Jia-Hau, Ko, Bo-Sheng, Yao, Ming, Chou, Wen-Chien, Lin, Hui-Chi, Chen, Yee-Chun, Tsay, Woei, Tang, Jih-Luh, Chang, Shan-Chwen, Tien, Hwei-Fang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.04.2013; Public Library of Science (PLoS)
• Subjects: Abscess - complications; Abscess - microbiology; Acute Disease; Acute leukemia; Acute lymphatic leukemia; Acute lymphoblastic leukemia; Acute myeloid leukemia; Adolescent; Adult; Aged; Anaerobes; Antibiotics; Bacilli; Bacteremia; Bacterial Infections - complications; Bleeding; Blood diseases; Candidemia; Chemotherapy; Cocci; Colon; Disease control; E coli; Elderly; Elderly people; Empirical analysis; Epidemiology; Escherichia coli; Ethics; Female; Fistula; Geriatrics; Gram-negative bacilli; Gram-positive cocci; Health care facilities; Hematology; Hospitals; Humans; Infection; Infections; Insurance claims; Internal medicine; Intervention; Klebsiella; Laboratories; Leukemia; Leukemia - complications; Lymphatic leukemia; Male; Markov analysis; Medical centers; Medical records; Medicine; Microbiology; Middle Aged; Mortality; Multivariate Analysis; Mycoses - complications; Myeloid leukemia; Neutropenia; Older people; Pain; Pathogens; Patients; Rectal Fistula - complications; Rectal Fistula - microbiology; Retrospective Studies; Review boards; Sepsis; Septic shock; Studies; Surgery; Systematic review; Young Adult; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0060624

Perianal infection is a common problem for patients with acute leukemia. However, neutropenia and bleeding tendency are relatively contraindicated to surgical intervention. The epidemiology, microbiology, clinical manifestations and outcomes of perianal infection in leukemic patients are also rarely discussed. The medical records of 1102 adult patients with acute leukemia at a tertiary medical center in Taiwan between 2001 and 2010 were retrospectively reviewed and analyzed. The prevalence of perianal infection was 6.7% (74 of 1102) in adult patients with acute leukemia. Twenty-three (31%) of the 74 patients had recurrent episodes of perianal infections. Patients with acute myeloid leukemia had higher recurrent rates than acute lymphoblastic leukemia patients (p = 0.028). More than half (n = 61, 53%) of the perianal infections were caused by gram-negative bacilli, followed by gram-positive cocci (n = 36, 31%), anaerobes (n = 18, 15%) and Candida (n = 1, 1%) from pus culture. Eighteen patients experienced bacteremia (n = 24) or candidemia (n = 1). Overall 41 (68%) of 60 patients had polymicrobial infection. Escherichia coli (25%) was the most common micro-organism isolated, followed by Enterococcus species (22%), Klebsiella pneumoniae (13%), and Bacteroides species (11%). Twenty-five (34%) of 74 patients received surgical intervention. Acute leukemia patients with surgically managed anal fistulas tended to have fewer recurrences (p = 0.067). Four (5%) patients died within 30 days after diagnosis of perianal infection. Univariate analysis of 30-day survival revealed the elderly (≧ 65 years) (p = 0.015) and patients with shock (p<0.001) had worse outcome. Multivariate analysis showed septic shock to be the independent predictive factor of 30-day crude mortality of perianal infections (p = 0.016). Perianal infections were common and had high recurrence rate in adult patients with acute leukemia. Empirical broad-spectrum antibiotics with anaerobic coverage should be considered. Shock independently predicted 30-day crude mortality. Surgical intervention for perianal infection remains challenging in patients with acute leukemia.