Antidepressants and Gastric Cancer: A Nationwide Population-Based Nested Case-Control Study

• Published in: PloS one Vol. 10; no. 11; p. e0143668
• Main Authors: Hsieh, Yi-Hsuan, Chiu, Wei-Che, Lin, Chiao-Fan, Chan, Hsiang-Lin, Liang, Hsin-Yi, Lee, Yena, McIntyre, Roger S., Chen, Vincent Chin-Hung
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.11.2015; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Amine oxidase (flavin-containing); Antidepressants; Antidepressive Agents - adverse effects; Bupropion; Cancer; Case-Control Studies; Child & adolescent psychiatry; Comorbidity; Complications and side effects; Confounding Factors (Epidemiology); Data processing; Datasets; Dosage and administration; Epidemiology; Exposure; Female; Gastric cancer; Health insurance; Health risk assessment; Health risks; Hospitals; Humans; Hypotheses; Illnesses; Incidence; Inhibitors; Male; Medical diagnosis; Medical research; Middle Aged; Nonsteroidal anti-inflammatory drugs; Norepinephrine; Oncology; Population; Population studies; Population Surveillance; Population-based studies; Regression analysis; Regression models; Risk; Risk factors; Serotonin; Socioeconomic Factors; Stomach cancer; Stomach Neoplasms - epidemiology; Stomach Neoplasms - etiology; Studies; Systematic review; Taiwan - epidemiology; Ulcers; Young Adult; Taiwan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0143668

To our knowledge, no epidemiological study has reported on whether an association between antidepressant exposure and gastric cancer exists. Herein, we aim to investigate the possible association between antidepressant exposure and gastric cancer incidence. Using a nested case-control design, we identified 26289 cases with gastric cancer and 127984 controls from Taiwan's National Health Insurance Research Database (NHIRD). The data were analyzed using a conditional logistic regression model adjusting for possible confounding variables. We found antidepressant use did not increase the risk of gastric cancer. The lack of an association between antidepressant prescription and elevated gastric cancer incidence was apparent for across selective serotonin-reuptake inhibitors (SSRIs), tricyclic agents (TCAs), serotonin-norepinephrine reuptake inhibitors (SNRIs), reversible inhibitors of monoamine oxidase A (RIMA), trazodone, mirtazapine and bupropion. There were slightly decreased gastric cancer risks of SSRIs use (≧28 DDD group, adjusted OR = 0.87; 95% CI = 0.78-0.96). Sensitive analysis showed SSRIs, TCAs, and SNRIs did not increase gastric cancer risks significantly even in the group with peptic ulcer history. An association between antidepressant exposure and gastric cancer was not apparent in this analysis.