Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies

• Published in: PloS one Vol. 12; no. 9; p. e0185283
• Main Authors: Jakobsen, Kathrine Kronberg, Grønhøj, Christian, Jensen, David H, Fischer-Nielsen, Anne, Hjuler, Thomas, von Buchwald, Christian
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.09.2017; Public Library of Science (PLoS)
• Subjects: Airway management; Animals; Asthma; Audiology; Biology and Life Sciences; Bone marrow; Care and treatment; Development and progression; Endoscopy; Engineering; Fibrosis; Genetic aspects; Humans; Inflammation; Inflammatory response; Intubation; Larynx - pathology; Libraries; Literature reviews; Medicine and Health Sciences; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Mesenchyme; Morbidity; Ostomy; Otolaryngology; Physiological aspects; Regeneration (physiology); Regenerative medicine; Research and Analysis Methods; Respiratory tract; Scars; Scientific papers; Search engines; Skin & tissue grafts; Stem cell transplantation; Stem cells; Stenosis; Studies; Surgery; Therapy; Tissue engineering; Tracheal Stenosis - complications; Tracheal Stenosis - pathology; Tracheal Stenosis - surgery; Transplants & implants; Treatment Outcome; Denmark
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0185283

Laryngotracheal stenosis (LTS) can be either congenital or acquired. Laryngeal stenosis is most often encountered after prolonged intubation. The mechanism for stenosis following intubation is believed to be hypertrophic scarring. Mesenchymal stem cells (MSCs) therapy has shown promising results in regenerative medicine. We aimed to systematically review the literature on MSC therapy for stenosis of the conductive airways. PubMed, EMBASE, Google Scholar and the Cochrane Library were systematically searched from January 1980-January 2017 with the purpose of identifying all studies addressing the effect of MSC therapy on the airway. We assessed effect on inflammation, fibrosis, and MSC as a component in tissue engineering for treating defects in the airway. We identified eleven studies (n = 256 animals) from eight countries evaluating the effect of MSCs as a regenerative therapy in the upper airways. The studies indicate that MSC therapy may lead to a more constructive inflammatory response as well as support tissue regeneration. There may be a favorable effect of MSCs in inhibiting inflammation and as a component in tissue engineering. Given the heterogeneous nature of the included animal studies, any clear conclusion regarding the effect of tracheal stenosis in human subjects cannot be drawn. The included preclinical studies are however encouraging for further research.