Association of type 2 diabetes with periodontitis and tooth loss in patients undergoing hemodialysis

• Published in: PloS one Vol. 17; no. 5; p. e0267494
• Main Authors: Mikami, Risako, Mizutani, Koji, Matsuyama, Yusuke, Gohda, Tomohito, Gotoh, Hiromichi, Aoyama, Norio, Matsuura, Takanori, Kido, Daisuke, Takeda, Kohei, Saito, Natsumi, Fujiwara, Takeo, Izumi, Yuichi, Iwata, Takanori
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.05.2022; Public Library of Science (PLoS)
• Subjects: Age; Agreements; Biochemistry; Biology and Life Sciences; Body mass index; Care and treatment; Coefficients; Complications and side effects; Confidence intervals; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Disease control; Edentulous; End-stage renal disease; Female; Glucose; Gum disease; Hemodialysis; Hemoglobin; Humans; Inflammation; Kidney diseases; Male; Medicine and Health Sciences; Patient outcomes; Patients; Periodontal disease; Periodontal diseases; Periodontitis; Periodontitis - complications; Regression analysis; Regression models; Renal Dialysis; Risk factors; Statistical analysis; Subgroups; Teeth; Tooth loss; Tooth Loss - complications; Type 2 diabetes; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0267494

Limited evidence are available regarding the influence of diabetes on periodontitis in hemodialysis patients, although the association between diabetes and periodontal disease is well-known. This study aimed to investigate the influence of type 2 diabetes mellitus (T2D) and its control level on periodontal disease and the number of missing teeth in patients undergoing hemodialysis. A single-center cross-sectional study was conducted on 246 Japanese patients with end-stage renal disease undergoing hemodialysis. Comprehensive medical and dental examinations were performed. The association between severity of periodontitis and T2D was examined by multiple ordered logistic regression analysis. A multiple linear regression model was fitted to assess the association of periodontal probing depth (PPD) ≥4 mm and the number of missing teeth with T2D (n = 125). A subgroup analysis involving only the patients with T2D was performed to investigate the factors associated with missing teeth among them. After adjusting for confounders, the classification of periodontitis severity was significantly advanced in patients with T2D (odds ratio: 1.64, 95% confidence interval [CI]: 1.02-2.65, p = 0.04). The proportion of PPD≥4 mm sites and the number of missing teeth was significantly associated with T2D (coefficient: 4.1 and 5.7, 95% CI: 0.2-8.0 and 3.4-8.0, p = 0.04 and <0.001, respectively). Subgroup analysis of T2D patients revealed that glycoalbumin levels (coefficient: 0.4, 95% CI: 0.03-0.80, p = 0.03), but not hemoglobin A1c levels (coefficient: 0.8, 95% CI: -1.0-2.7, p = 0.37), were significantly associated with the number of missing teeth. T2D was significantly associated with periodontitis and the number of missing teeth in hemodialysis patients. Moreover, it is first documented that poor glycemic control, as determined by glycoalbumin levels, was significantly associated with the number of missing teeth in hemodialysis patients with T2D.