The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility

• Published in: PloS one Vol. 8; no. 9; p. e70656
• Main Authors: Wang, Ping-Yu, Gao, Zong-Hua, Jiang, Zhong-Hua, Li, Xin-Xin, Jiang, Bao-Fa, Xie, Shu-Yang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.09.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Breast cancer; Breast Neoplasms - genetics; Cancer; Case-Control Studies; Chromosomes; Confidence intervals; Disease susceptibility; Epidemiology; Female; Gene Frequency; Genes; Genetic aspects; Genetic Association Studies; Genetic Predisposition to Disease; Genotypes; Health aspects; Health risk assessment; Health risks; Humans; Liver cancer; Medical ethics; Meta-analysis; MicroRNA; MicroRNAs; MicroRNAs - genetics; miRNA; Oncology, Experimental; Polymorphism, Single Nucleotide; Public health; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statistical analysis; Studies; Xin Li; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0070656

Previous studies have investigated the association between single nucleotide polymorphisms (SNPs) located in microRNAs (miRNAs) and breast cancer susceptibility; however, because of their limited statistical power, many discrepancies are revealed in these studies. The meta-analysis presented here aimed to identify and characterize the roles of miRNA SNPs in breast cancer risk, and evaluate the associations of polymorphisms in miR-146a rs2910164, miR-196a rs11614913 and miR-499 rs3746444 with breast cancer susceptibility, respectively. The PubMed and Embases databases were searched updated to 31(st) December, 2012. The complete data of polymorphisms in miR-146a rs2910164, miR-196a rs11614913 and miR-499 rs3746444 from case-control studies for breast cancer were analyzed by odds ratios (ORs) with 95% confidence intervals (CIs) to reveal the associations of SNPs in miRNAs with breast cancer susceptibility. Totally, six studies for rs2910164 in miR-146a, involving 4225 cases and 4469 controls; eight studies for rs11614913 in miR-196a, involving 4110 cases and 5100 controls; and three studies of rs3746444 in miR-499, involving 2588 cases and 3260 controls, were investigated in the meta-analysis. The rs11614913 (TT+CT) genotype of miR-196a2 was revealed to be associated with a decreased breast cancer susceptibility compared with the CC genotypes (OR = 0.906, 95% CI: 0.825-0.995, P = 0.039); however, no significant associations were observed between rs2910164 in miR-146a (or rs3746444 in miR-499) and breast cancer susceptibility. This meta-analysis demonstrates the compelling evidence that the rs11614913 CC genotype in miR-196a2 increases breast cancer risk, which provides useful information for the early diagnosis and prevention of breast cancer.