Intraocular Pressure Reduction Is Associated with Reduced Venous Pulsation Pressure

• Published in: PloS one Vol. 11; no. 1; p. e0147915
• Main Authors: Morgan, William H, House, Philip H, Hazelton, Martin L, Betz-Stablein, Brigid D, Chauhan, Balwantray C, Viswanathan, Ananth, Yu, Dao-Yi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.01.2016; Public Library of Science (PLoS)
• Subjects: Aged; Automation; Bioinformatics; Biology and Life Sciences; Calibration; Consent; Cornea; Cornea - blood supply; Cornea - pathology; Corneal Pachymetry; Data analysis; Data processing; Endothelium; Female; Females; Glaucoma; Glaucoma - diagnosis; Glaucoma - pathology; Glaucoma - physiopathology; Humans; Intraocular Pressure; Logistic Models; Male; Medicine and Health Sciences; Middle Aged; Ophthalmodynamometry; Optic nerve; Patients; Physiological aspects; Pressure; Pressure reduction; Pulsatile Flow; Pulsation; Reduction; Regression analysis; Regression models; Retina; Retinal Vein - physiopathology; Tonometry, Ocular; Veins & arteries; Visual field; Visual Fields; United Kingdom; New Zealand; Australia
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0147915

To explore whether alterations in intraocular pressure (IOP) affect vein pulsation properties using ophthalmodynamometric measures of vein pulsation pressure. Glaucoma patients had two retinal vein pulsation pressure (VPP) measurements from upper and lower hemiveins performed by ophthalmodynamometry at least 3 months apart. All subjects had VPP and IOP recorded at two visits, with standard automated perimetry, central corneal thickness (CCT) recorded at the initial visit. Where venous pulsation was spontaneous ophthalmodynamometry could not be performed and VPP was considered equal to IOP. Change in VPP was calculated and binarized with reduction in pressure scored 1 and no change or increase scored as 0. Data analysis used a mixed logistic regression model with change in VPP as response variable and change in IOP, visual field loss (mean deviation), CCT and time interval as explanatory variables. 31 subjects (20 females) with mean age 60 years (sd 11) were examined with change in VPP being significantly associated with change in IOP (odds ratio 1.6/mmHg, 95% CI 1.2 to 2.1 in the glaucoma patients but not suspect patients (p = 0.0005). Change in VPP is strongly associated with change in IOP such that a reduced intraocular pressure is associated with a subsequent reduction in VPP. This indicates that reduced IOP alters some retinal vein properties however the nature and time course of these changes is not known.