Acute toxicity and genotoxicity of silver nanoparticle in rats

• Published in: PloS one Vol. 12; no. 9; p. e0185554
• Main Authors: Wen, Hairuo, Dan, Mo, Yang, Ying, Lyu, Jianjun, Shao, Anliang, Cheng, Xiang, Chen, Liang, Xu, Liming
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.09.2017; Public Library of Science (PLoS)
• Subjects: Aberration; Acute toxicity; Animal tissues; Animals; Archives & records; Biology and Life Sciences; Body weight; Bone marrow; Breakage; Carcinogens; Chronic toxicity; Damage; Deoxyribonucleic acid; DNA; Dosage; Drug dosages; Engineering and Technology; Female; Food; Gene expression; Genotoxicity; Heart; Hematology; Immune system; Irritation; Kidneys; Laboratories; Liver; Lungs; Medical equipment; Medical technology; Medicine and Health Sciences; Metal Nanoparticles - chemistry; Metal Nanoparticles - toxicity; Microscopy, Electron, Transmission; Mutagenicity Tests; Nanoparticles; Organs; Physiological aspects; Polyploidy; Rats; Rats, Sprague-Dawley; Rodents; Silver; Silver - chemistry; Spleen; Sucrose; Sugar; Thymus; Tissue Distribution; Toxicity; Toxicology; Transmission electron microscopy; China; Beijing China

The potential risk of a nanoparticle as a medical application has raised wide concerns, and this study aims to investigate silver nanoparticle (AgNP)-induced acute toxicities, genotoxicities, target organs and the underlying mechanisms. Sprague-Dawley rats were randomly divided into 4 groups (n = 4...