Non-mycosis fungoides cutaneous lymphomas in a referral center in Taiwan: A retrospective case series and literature review

• Published in: PloS one Vol. 15; no. 1; p. e0228046
• Main Authors: Liu, Kwei-Lan, Tsai, Wen-Chien, Lee, Chih-Hung
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.01.2020; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Albumins; Analysis; Anaplastic large-cell lymphoma; B-cell lymphoma; Biology and Life Sciences; Cell survival; Child; Classification; Demographics; Dermatology; Female; Females; Fungal infections; Hospitals; Humans; L-Lactate dehydrogenase; Laboratories; Lactate dehydrogenase; Lactic acid; Leukemia; Literature reviews; Lymphatic system; Lymphocytes B; Lymphocytes T; Lymphoid tissue; Lymphoma; Lymphoma, T-Cell, Cutaneous - pathology; Male; Males; Mantle cell lymphoma; Medical prognosis; Medicine and Health Sciences; Middle Aged; Mucosa; Mucosal-associated lymphoid tissue; Mycoses; Mycosis; Mycosis fungoides; Mycosis Fungoides - pathology; Natural killer cells; Neoplasm Staging; Non-Hodgkin's lymphomas; People and Places; Prognosis; Referral and Consultation; Retrospective Studies; Sezary Syndrome - pathology; Skin; Survival; Survival Analysis; T cells; T-cell lymphoma; Taiwan; Thrombocytopenia; Tumors; Young Adult; Taiwan; South Korea; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0228046

While mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous lymphomas (CLs), there is limited data about non-MF/SS CLs. We aimed to evaluate clinical characteristics of non-MF/SS CLs. A retrospective analysis evaluated patients with non-MF/SS CLs covering a period of 17 years. The records of 59 patients with non-MF/SS CLs were reviewed for demographic profiles, clinical features, and survival outcomes. Our series consisted of 38 non-MF/SS cutaneous T-cell lymphomas (CTCLs) and 21 cutaneous B-cell lymphomas (CBCLs). In the group of non-MF/SS CTCLs including 33 primary and five secondary cases, there were cases of anaplastic large cell lymphoma (15.3% of non-MF/SS CLs), extranodal natural killer/ T-cell lymphoma (13.5%), peripheral T-cell lymphoma, not otherwise specified (13,5%), adult T-cell leukemia/lymphoma (8.5%), subcutaneous panniculitis-like T-cell lymphoma (6.8%) and angioimmunoblastic T-cell lymphoma (6.8%). In the group of CBCLs including nine primary and 12 secondary cases, there were cases of diffuse large B-cell lymphoma (22.0%), mantle cell lymphoma (5.1%), extranodal marginal lymphoma of mucosa associated lymphoid tissue (3.4%), follicle center lymphoma (3.4%) and intravascular large B-cell lymphoma (1.7%). The overall survivals were 57 months for non-MF/SS CTCLs and 41.5 months for CBCLs. Elevated serum lactate dehydrogenase level, thrombocytopenia, multiple anatomical sites of skin involvement and lower albumin level may be associated with poor prognosis in non-MF/SS CTCLs, but the latter two were not in CBCLs. With this series, we hope to provide indigenous data and outcome of non-MF/SS CLs. The overall survival of non-MF/SS CTCLs was better than CBCLs.