High-performance wireless powering for peripheral nerve neuromodulation systems
Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological chall...
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Published in | PloS one Vol. 12; no. 10; p. e0186698 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Public Library of Science
24.10.2017
Public Library of Science (PLoS) |
Subjects | |
Online Access | Get full text |
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Summary: | Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model. The increased performance is enabled by the generation of a focused and circularly polarized field that enhances efficiency and provides immunity to polarization misalignment. These performance characteristics establish the clinical potential of wireless powering for emerging therapies based on neuromodulation. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: A.S.Y.P. and Y.T. received personal compensation for consulting from Center for Innovation and Strategic Collaboration, St. Jude Medical, Inc. A.S.Y.P. received research support through her institution from St. Jude Medical. J.S.H. and A.S.Y.P. have disclosed the wireless powering system to the Stanford Office of Technology Licensing for potential therapy applications. This does not alter our adherence to PLOS ONE policies on sharing data and materials. |
ISSN: | 1932-6203 1932-6203 |
DOI: | 10.1371/journal.pone.0186698 |