High-performance wireless powering for peripheral nerve neuromodulation systems

Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological chall...

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Published inPloS one Vol. 12; no. 10; p. e0186698
Main Authors Tanabe, Yuji, Ho, John S, Liu, Jiayin, Liao, Song-Yan, Zhen, Zhe, Hsu, Stephanie, Shuto, Chika, Zhu, Zi-Yi, Ma, Andrew, Vassos, Christopher, Chen, Peter, Tse, Hung Fat, Poon, Ada S Y
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 24.10.2017
Public Library of Science (PLoS)
Subjects
Animals
Bioelectricity
Biology and Life Sciences
Collaboration
Computer engineering
Devices
Electrical engineering
Electrodes
Engineering and Technology
Equipment Design
Female
Genetic aspects
Immunity
Medicine
Medicine and Health Sciences
Methods
Miniaturization
Misalignment
Nervous system
Neural stimulation
Neuromodulation
Pain
Peripheral nerves
Peripheral Nerves - physiology
Physical Sciences
Physiological aspects
Spinal cord injuries
Swine
Transmitters
Vagus nerve
Wireless Technology - instrumentation
United States
China
Singapore
Hong Kong
United States > US
California
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Summary:Neuromodulation of peripheral nerves with bioelectronic devices is a promising approach for treating a wide range of disorders. Wireless powering could enable long-term operation of these devices, but achieving high performance for miniaturized and deeply placed devices remains a technological challenge. We report the miniaturized integration of a wireless powering system in soft neuromodulation device (15 mm length, 2.7 mm diameter) and demonstrate high performance (about 10%) during in vivo wireless stimulation of the vagus nerve in a porcine animal model. The increased performance is enabled by the generation of a focused and circularly polarized field that enhances efficiency and provides immunity to polarization misalignment. These performance characteristics establish the clinical potential of wireless powering for emerging therapies based on neuromodulation.
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Competing Interests: A.S.Y.P. and Y.T. received personal compensation for consulting from Center for Innovation and Strategic Collaboration, St. Jude Medical, Inc. A.S.Y.P. received research support through her institution from St. Jude Medical. J.S.H. and A.S.Y.P. have disclosed the wireless powering system to the Stanford Office of Technology Licensing for potential therapy applications. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186698