The Effect of ShenQi FuZheng Injection in Combination with Chemotherapy versus Chemotherapy Alone on the Improvement of Efficacy and Immune Function in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

• Published in: PloS one Vol. 11; no. 3; p. e0152270
• Main Authors: Dedong, Cao, Huilin, Xu, Anbing, He, Ximing, Xu, Wei, Ge
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.03.2016; Public Library of Science (PLoS)
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Astragalus; Biology and Life Sciences; Cancer; Cancer therapies; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - immunology; Carcinoma, Non-Small-Cell Lung - pathology; Care and treatment; Causes of; CD3 antigen; CD4 antigen; CD8 antigen; Cell-mediated immunity; Chemotherapy; Chinese medicine; Clinical trials; Criteria; Cytokines; Cytotoxicity; Data analysis; Data processing; Drugs, Chinese Herbal - therapeutic use; Effectiveness; FDA approval; Gastric cancer; Herbal medicine; Humans; Immune response; Immunity; Immunity, Cellular - drug effects; Injection; Lung cancer; Lung diseases; Lymphocytes; Medical research; Medicine and Health Sciences; Meta-analysis; Non-small cell lung carcinoma; Oncology; Patients; Physical Sciences; Quality assessment; Quality of life; Randomized Controlled Trials as Topic; Regression analysis; Research and Analysis Methods; Risk factors; Stomach cancer; Studies; Systematic review; Tumors; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0152270

To evaluate the effect of ShenQi FuZheng Injection (SFI) on cellular immunity and clinical efficacy in patients with advanced non small cell lung cancer(NSCLC) when combined with chemotherapy. Electronic databases including EMBASE, PUBMED, the conference proceedings of the American Society of Clinical Oncology (ASCO), Cochrane, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biological Medical disc(CBM) were searched, until July, 2015. The randomized controlled clinical studies reporting results of efficacy and immune function were collected according to the inclusion criteria. Cochrane handbook 5.1.0 was applied to assess the quality of included trials and Revman 5 software was used for data analysis. Fifteen studies including 1006 cases of advanced NSCLC were included based on the inclusion criteria. The results of meta-analysis showed that there were significant differences in percentages of CD3+ cells (SMD = 13.48; 95%CI: 8.11-18.85; p<0.01), CD4+ cells (SMD = 10.78; 95%CI, 6.38-15.18; p<0.01), NK [WMD = 8.59, 95% CI(3.97, 13.21), p = 0.003], and ratio of CD4+/ CD8+ (SMD = 0.32; 95%: 0.28-0.36; p<0.01) between SFI combination group and control group, whereas the difference was not significant in CD8+ (SMD = -1.44; 95%CI, -4.53-1.65; p = 0.36). Funnel plot, Begg's rank correlation test and Egger's linear regression analysis indicated that there was significant publication bias across studies. SFI is effective to improve the efficacy of chemotherpay and function of cellular immunity in NSCLC patients, however, high quality RCTs are needed to further confirm the findings.