Relationship between the washout rate of I-123 MIBG scans and autonomic function in Parkinson's disease

• Published in: PloS one Vol. 15; no. 3; p. e0229860
• Main Authors: Jeong, Young Jin, Jeong, Ji-Eun, Cheon, Sang-Myung, Yoon, Byeol-A, Kim, Jae Woo, Kang, Do-Young
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.03.2020; Public Library of Science (PLoS)
• Subjects: Autonomic nervous system; Biology and Life Sciences; Blood pressure; Correlation; Correlation analysis; Dementia; Diagnostic imaging; Diastolic pressure; Differential diagnosis; Differential thermal analysis; Diseases; Drug dosages; Evaluation; Fluorine isotopes; Heart failure; Hospitals; Hypotension; Medical diagnosis; Medical schools; Medicine and Health Sciences; Movement disorders; Neurodegenerative diseases; Neurology; Nuclear medicine; Orthostatic hypotension; Parkinson's disease; Positron emission; Positron emission tomography; Radioisotopes; Research and Analysis Methods; Studies; Systolic pressure; Tomography; Volumetric analysis; United States > US; South Korea
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0229860

We have evaluated the clinical significance of the washout rate (WR) on I-123 MIBG scans through the analysis of the relationship between the I-123 MIBG scans and autonomic status in patients with Parkinson's disease (PD). Sixty patients with clinical PD who had decreased HMR were enrolled. An autonomic symptom was evaluated using a head-up tilt test and the Composite Autonomic Severity Score (CASS). An I-123 MIBG scan and F-18 FP-CIT positron emission tomography (PET) were performed. All of the patients were classified into three groups according to the WR. The differences in patient characteristics and the imaging parameters among the three groups were evaluated, and a correlation analysis was also performed. The frequency of orthostatic hypotension was significantly different among the three groups. The difference in systolic pressure (dSysPr) and the difference in diastolic pressure (dDiaPr) of group 3 was significantly larger than those of groups 1 and 2. From the correlation analysis, it can be seen that age, Hoehn and Yahr (H&Y) stage, dSysPr, and dDiaPr had a weak positive correlation with the WR. The total CASS score was significantly higher in group 3 compared with groups 1 and 2. The WR had a moderate positive correlation with the cardiosympathetic score and the total CASS score. The WR is related to autonomic dysfunction. An I-123 MIBG cardiac scan is considered to be a good method to evaluate not only the differential diagnosis of Parkinson's disease but also the degree of autonomic dysfunction.