Obesity, insulin resistance and their interaction on liver enzymes

• Published in: PloS one Vol. 16; no. 4; p. e0249299
• Main Authors: Liu, Chenbing, Shao, Min, Lu, Ling, Zhao, Chenzhao, Qiu, Lihong, Liu, Zhong
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 21.04.2021; Public Library of Science (PLoS)
• Subjects: Adults; Age; Analysis; Biology and Life Sciences; Body mass index; Cholesterol; Complications and side effects; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diet; Dietary intake; Editing; Enzymes; Evaluation; Fatty liver; Glucose; Homeostasis; Hospitals; Insulin; Insulin resistance; Liver; Management; Medicine; Medicine and Health Sciences; Metabolic syndrome; Obesity; Overweight; Regression analysis; Resistance factors; Reviews; Risk analysis; Risk factors; Statistical analysis; Variables; Weight; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0249299

To investigate weight status, insulin resistance assessed by HOMA-IR, and their interaction on liver function in non-diabetic Chinese adults. A total of 7066 subjects were included, and divided into normal weight (n = 3447), overweight (n = 2801), and obese (n = 818) groups. Data including weight, height, waist circumference, fasting blood glucose, fasting insulin, total cholesterol, triglycerides, y-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were acquired. In multi-linear regression analysis for liver enzymes as dependent variables, insulin resistance emerged as a determinant of ALT (β = 0.165, P<0.001), AST (β = 0.040, P<0.001) and GGT (β = 0.170, P<0.001) after adjusting for age, sex, body mass index, triglyceride, and cholesterol. Interactions between insulin resistance and weight status by body mass index were observed in ALT (P<0.001), AST (P<0.001) and GGT (P = 0.0418). Insulin resistance had significant associations with greater risk of elevated ALT, AST and GGT level in non-diabetic Chinese adults, especially among those who were overweight/ obese.