In vitro assessment of nanosilver-functionalized PMMA bone cement on primary human mesenchymal stem cells and osteoblasts

• Published in: PloS one Vol. 9; no. 12; p. e114740
• Main Authors: Pauksch, Linda, Hartmann, Sonja, Szalay, Gabor, Alt, Volker, Lips, Katrin S
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.12.2014; Public Library of Science (PLoS)
• Subjects: Aminoglycosides; Analysis; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics; Apoptosis - drug effects; Bacteria; Biocompatibility; Biological products; Biology and Life Sciences; Biomaterials; Biomedical materials; Bone cements; Bone Cements - chemistry; Bone implants; Cell culture; Cell differentiation; Cell Differentiation - drug effects; Cell number; Cell Proliferation - drug effects; Cells, Cultured; Cement; Cytotoxicity; Differentiation (biology); Engineering and Technology; Gentamicin; Gentamicins - pharmacology; Health aspects; Humans; In Vitro Techniques; Infection; Infections; Laboratories; Materials Testing; Mesenchymal stem cells; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - drug effects; Mesenchymal Stromal Cells - metabolism; Mesenchyme; Morphology; Multidrug resistance; Multidrug resistant organisms; Nanoparticles; Nanoparticles - chemistry; Orthopedics; Osteoblasts; Osteoblasts - cytology; Osteoblasts - drug effects; Osteoblasts - metabolism; Osteogenesis; Penicillin; Polymethyl methacrylate; Polymethyl Methacrylate - chemistry; Polymethylmethacrylate; Prostheses; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Silver; Silver - chemistry; Stem cells; Stress; Stresses; Sulfur; Supplementation; Surgery; Surgical implants; Viability; Germany

Peri-prosthetic infections caused by multidrug resistant bacteria have become a serious problem in surgery and orthopedics. The aim is to introduce biomaterials that avoid implant-related infections caused by multiresistant bacteria. The efficacy of silver nanoparticles (AgNP) against a broad spectr...