Diagnostic performance of diffusion-weighted imaging for prostate cancer: Peripheral zone versus transition zone

• Published in: PloS one Vol. 13; no. 6; p. e0199636
• Main Authors: Lee, Hakmin, Hwang, Sung Il, Lee, Hak Jong, Byun, Seok-Soo, Lee, Sang Eun, Hong, Sung Kyu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.06.2018; Public Library of Science (PLoS)
• Subjects: Aged; Biology and Life Sciences; Biopsy; Cancer; Cancer surgery; Care and treatment; Comparative analysis; Diagnosis; Diagnostic systems; Diffusion; Diffusion Magnetic Resonance Imaging; Evaluation; Humans; Image Interpretation, Computer-Assisted; Lesions; Magnetic resonance; Magnetic resonance imaging; Male; Medical diagnosis; Medical imaging; Medicine; Medicine and Health Sciences; Middle Aged; Neoplasm Grading; NMR; Nuclear magnetic resonance; Patients; Prospective Studies; Prostate - diagnostic imaging; Prostate - pathology; Prostate - surgery; Prostate cancer; Prostatectomy; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Prostatic Neoplasms - surgery; Quality; Regression analysis; Research and Analysis Methods; Retrospective Studies; Review boards; Surgery; Tumors; Urological surgery; Urology
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0199636

Diffusion-weighted imaging (DWI) has been shown to be an important component of multiparametric magnetic resonance imaging (mpMRI). We compared performance of DWI for detection of prostate cancer (PCa) in peripheral zone (PZ) and transition zone (TZ) of prostate. We reviewed data of 460 subjects who underwent preoperative 3.0-Tesla mpMRI and subsequently radical prostatectomy. Level of suspicion for PCa was graded using 5-grade Likert-scale from DWI. Topographic analyses were performed for location of tumor foci at each surgical specimen. Among those with DWI grade ≥ III, we analyzed concordance rate on the location of radiologic and pathologic index lesions between DWI and surgical specimens. Among 460 patients, 351 (76.3%) patients showed suspicious DWI lesions (57.5% in PZ, 42.5% in TZ). Multivariates regression analyses revealed significant associations between high DWI grade and adverse pathologic outcomes including pathologic stage, Gleason score, tumor volume and extracapsular extension (all p < 0.05). Overall concordance rates between DWI and surgical specimen were 75.8%, significantly higher in PZ than TZ (82.2% vs. 67.1% p = 0.002). Such concordance rate showed a positive linear association with increase in DWI grading (p < 0.001). Among 109 patients with DWI grade I-II, 28 (25.7%) harbored high grade disease (pathologic Gleason score ≥ 4 + 3). DWI detects tumors in PZ of prostate more accurately than those in TZ. Such accuracy of DWI was shown to be more evident with higher DWI grade. Meanwhile, a negative DWI did not guarantee absence of high grade PCa.