High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma

• Published in: PloS one Vol. 9; no. 3; p. e90955
• Main Authors: Zhang, Yi-An, Zhu, Ji-Min, Yin, Jie, Tang, Wen-Qing, Guo, Yan-Mei, Shen, Xi-Zhong, Liu, Tao-Tao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2014; Public Library of Science (PLoS)
• Subjects: Antigens; Ataxia; Biology; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - surgery; Cell growth; Cell Line, Tumor; Cell migration; Cell Movement; Cell Proliferation; Cell survival; Female; Follow-Up Studies; Gene Expression; Hepatocellular carcinoma; Humans; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Medical prognosis; Medicine; Middle Aged; Myoclonus; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Prognosis; Protein binding; Ribonucleic acid; RNA; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; RNA-binding protein; RNA-Binding Proteins - antagonists & inhibitors; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Rodents; Survival; Survival Analysis; Tumor cell lines; Tumors
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0090955

Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.